DC Chemicals Limited
China
Product Name: N-ethylmaleimide
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Stocking Period: 10 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: N-Ethylmaleimide
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

128-53-0

128-53-0 structure

Name: N-ethylmaleimide
Chemical Name: N-ethylmaleimide
CAS Number: 128-53-0
Molecular Formula: C₆H₇NO₂
Molecular Weight: 125.13
Catalog: Organic raw materials Amino compound Amide compound
Create Date: 2018-03-10 08:00:00
Modify Date: 2025-08-20 18:36:29
N-Ethylmaleimide (NEM) is a cysteine protease inhibitor[1]. N-ethylmaleimide specific inhibits phosphate transport in mitochondria[2].

Name	N-ethylmaleimide
Synonyms	N-ethylmaleimide EINECS 204-892-4 1H-Pyrrole-2,5-dione, 1-ethyl- n-ethyl-maleimid MFCD00005509 1-ethylmaleimide N-ethyl-maleimide N-ethylmaleic imide ethvlmaleimide n-ethvlmaleimide 1-Ethyl-1H-pyrrole-2,5-dione N-Ethylmaleinimid Ethylmaleimide

Description	N-Ethylmaleimide (NEM) is a cysteine protease inhibitor[1]. N-ethylmaleimide specific inhibits phosphate transport in mitochondria[2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Metabolic Enzyme/Protease >> Cathepsin
Target	Cysteine protease[1]
References	[1]. Wu KH, et al. Cys32 and His105 are the critical residues for the calcium-dependent cysteine proteolyticactivity of CvaB, an ATP-binding cassette transporter. J Biol Chem. 2004 Jan 9;279(2):901-9. [2]. Hatase O , et al. Specific inhibition of phosphate transport in mitochondria by N-ethylmaleimide. Journal of Bioenergetics, 1973, 5(1):1-15.

Density	1.2±0.1 g/cm3
Boiling Point	210.0±9.0 °C at 760 mmHg
Melting Point	43-46 °C(lit.)
Molecular Formula	C₆H₇NO₂
Molecular Weight	125.13
Flash Point	73.3±0.0 °C
Exact Mass	125.047676
PSA	37.38000
LogP	0.68
Vapour Pressure	0.2±0.4 mmHg at 25°C
Index of Refraction	1.514
Storage condition	2-8°C
Stability	Stable. Combustible. Incompatible with strong oxidizing agents. Refrigerate.
Water Solubility	1 g/L (20 ºC)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UX9625000

CHEMICAL NAME :: 1H-Pyrrole-2,5-dione, 1-ethyl-

CAS REGISTRY NUMBER :: 128-53-0

BEILSTEIN REFERENCE NO. :: 0112448

LAST UPDATED :: 199710

DATA ITEMS CITED :: 15

MOLECULAR FORMULA :: C6-H7-N-O2

MOLECULAR WEIGHT :: 125.14

WISWESSER LINE NOTATION :: T5VNVJ B2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 17 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intracerebral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1669 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 750 nmol/L

REFERENCE :: 32YWA5 "Radiation Research, Biomedical, Chemical, and Physical Perspectives, Proceedings of the International Congress of Radiation Research, 5th, Seattle, 1974," Nygaard, O.F., et al., eds., New York, Academic Press, Inc., 1975 Volume(issue)/page/year: -,742,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4314 No. of Facilities: 132 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 2547 (estimated) No. of Female Employees: 1922 (estimated)

Symbol	GHS05, GHS06
Signal Word	Danger
Hazard Statements	H300-H311-H314-H317
Precautionary Statements	P264-P280-P301 + P310-P305 + P351 + P338-P310
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T+:Verytoxic;
Risk Phrases	R20/21;R28;R34;R43
Safety Phrases	S26-S28-S36/37/39-S45-S28A
RIDADR	UN 2928 6.1/PG 2
WGK Germany	3
RTECS	UX9625000
Packaging Group	II
Hazard Class	6.1
HS Code	2925190090

108-31-6

557-66-4

128-53-0

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 15 p. 4577 - 4580

4166-67-0

128-53-0

Literature: Gazzetta Chimica Italiana, , vol. 26 I, p. 438 Gazzetta Chimica Italiana, , vol. 18, p. 471,478 Gazzetta Chimica Italiana, , vol. 18, p. 476

1370477-99-8

128-53-0

1370477-97-6

Literature: Organic and Biomolecular Chemistry, , vol. 10, # 14 p. 2787 - 2792,6

128438-93-7

128-53-0

Literature: Journal of Enzyme Inhibition and Medicinal Chemistry, , vol. 27, # 1 p. 117 - 124

Precursor 4
108-31-6 557-66-4 4166-67-0 128438-93-7
DownStream 7
4166-67-0 2314-78-5 3671-01-0 77405-88-0
86497-77-0 90330-10-2 46785-28-8

HS Code	2925190090
Summary	2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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