477-19-0

477-19-0 structure

Name: (7α)-9,10-Dimethoxy-1-methyllycorenan-7-ol
Chemical Name: lycorenine
CAS Number: 477-19-0
Molecular Formula: C₁₈H₂₃NO₄
Molecular Weight: 317.379
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-05-24 08:00:00
Modify Date: 2025-08-29 18:13:35
Lycorenine is an alkaloid that has vasodepressor action. Lycorenine also exhibits anticancer and antibacterial activities[1][2][3].

Name	lycorenine
Synonyms	[2]Benzopyrano[3,4-g]indol-7-ol, 1,2,3,5,5a,7,11b,11c-octahydro-9,10-dimethoxy-1-methyl-, (5aR,7S,11bS,11cS)- ycorenine (7α)-9,10-Dimethoxy-1-methyllycorenan-7-ol

Description	Lycorenine is an alkaloid that has vasodepressor action. Lycorenine also exhibits anticancer and antibacterial activities[1][2][3].
Related Catalog	Research Areas >> Cancer Research Areas >> Cardiovascular Disease Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Lycorenine inhibits the cell viability, with IC50s of 0.8 and 1.2 μg/mL for LMTK and HEPG2 cells, respectively[2].
In Vivo	Lycorenine (1-10 mg/kg i.v.) produces dose-related decreases in blood pressure and heart rate in anesthetized rats[1].
References	[1]. Miyasaka K, et, al. Pharmacological studies of lycorenine, an alkaloid of Lycoris radiata Herb.: Vasodepressor mechanism in rats. Jpn J Pharmacol. 1979 Aug;29(4):605-22. [2]. Weniger B, et, al. Cytotoxic activity of Amaryllidaceae alkaloids. Planta Med. 1995 Feb;61(1):77-9. [3]. Gu D, et, al. Antibacterial Phytosterols and Alkaloids from Lycoris radiate. Natural Product Sciences. 2014 Jou; 20(2): 107-112.