- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Tomatidine
- Price: ￥1968.0/20mg
- Purity: 98.0%
- Stocking Period: 2 Day
- Contact: Liu jia
- Henan Tianfu Chemical Co., Ltd.
- China
- Product Name: TOMATIDINE
- Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
- Purity: 99.0%
- Stocking Period: Inquiry
- Contact: Anson
77-59-8
77-59-8 structure
- Name: Tomatidine
- Chemical Name: tomatidine
- CAS Number: 77-59-8
- Molecular Formula: C27H45NO2
- Molecular Weight: 415.652
- Catalog: Natural product Alkaloid
- Create Date: 2018-06-12 17:08:33
- Modify Date: 2024-01-02 18:54:50
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Tomatidine acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling.
| Name | tomatidine |
|---|---|
| Synonyms |
(3b,5a,22b,25S)-Spirosolan-3-ol
(3β,5α,22β,25S)-spirosolan-3-ol Spirosolan-3-ol, (3β,5α,22β,25S)- (9CI) 5alpha-Tomatidan-3beta-ol (22S,25S)-5α-spirosolan-3β-ol (2S,4aS,4bS,5'S,6aS,6bR,7S,8S,9aS,10aS,10bR,12aS)-4a,5',6a,7-Tetramethyloctadecahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-8,2'-piperidin]-2-ol (2S,4aS,4bS,5'S,6aS,6bR,7S,8S,9aS,10aS,10bR,12aS)-4a,5',6a,7-Tétraméthyloctadécahydrospiro[naphto[2',1':4,5]indéno[2,1-b]furane-8,2'-pipéridin]-2-ol 5a,20bF,22aF,25bF,27-azaspirostan-3b-ol (3β,5α,25S)-Spirosolan-3-ol Tomatidine Spirosolan-3-ol, (3β,5α,25S)- Tomatidin |
| Description | Tomatidine acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. |
|---|---|
| Related Catalog | |
| Target |
p65 JNK |
| In Vitro | Tomatidine decreases inducible NO synthase and COX-2 expression through suppression of I-κBα phosphorylation, NF-κB nuclear translocation and JNK activation, which in turn inhibits c-jun phosphorylation and Oct-2 expression. Tomatidine, solasodine and diosgenin (40 μM) show 66%, 22% and 41% inhibition of nitrite production, respectively. The iNOS protein is barely detectable in unstimulated cells but markedly increases after LPS treatment, and Tomatidine causes dose-dependent inhibition of LPS-induced iNOS expression. p65 is the major component of NF-κB in LPS-stimulated macrophages, the effect of Tomatidine on p65 DNA-binding activity is determined. In the presence of Tomatidine at 10-40 μM, the binding activity of NF-κB is suppressed in a dose-dependent manner. Tomatidine inhibits the phosphorylation of I-κB, blocks the I-κB production, and furthermore suppresses p65 NF-κB translocation to the nucleus and modulated binding activity[1]. |
| Cell Assay | RAW 264.7 cells, derived from murine macrophages, are cultured in DMEM supplemented with 10% endotoxin-free, heat-inactivated fetal calf serum, Penicillin (100 units/mL), and Streptomycin (100 μg/mL) in a 5% CO2 atmosphere at 37°C in a humidified incubator. For all assay, cell is plated at 2×105 cells/cm2 in culture dishes or plates. Treatment with vehicle (0.1% DMSO or 0.1% ethanol), test compounds and/or LPS is carried out under serum-free conditions[1]. |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 527.2±25.0 °C at 760 mmHg |
| Melting Point | 210.5℃ |
| Molecular Formula | C27H45NO2 |
| Molecular Weight | 415.652 |
| Flash Point | 272.7±23.2 °C |
| Exact Mass | 415.345032 |
| PSA | 41.49000 |
| LogP | 6.15 |
| Vapour Pressure | 0.0±3.1 mmHg at 25°C |
| Index of Refraction | 1.560 |
| Storage condition | -20°C |