919973-83-4
919973-83-4 structure
- Name: OF 1
- Chemical Name: of-1
- CAS Number: 919973-83-4
- Molecular Formula: C17H18BrN3O4S
- Molecular Weight: 440.311
- Catalog: Biochemical Inhibitor Epigenetics Epigenetic Reader Domain Inhibitor
- Create Date: 2017-05-10 18:51:24
- Modify Date: 2025-08-26 19:51:37
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OF-1 is a selective BRPF1B and BRPF2 bromodomain inhibitor with Kd values of 100 nM/500 nM for BRPF1B/BRPF2; 39-fold selectivity over BRD4.
| Name | of-1 |
|---|---|
| Synonyms |
4-Bromo-N-(6-methoxy-1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)-2-methylbenzenesulfonamide
Benzenesulfonamide, 4-bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-oxo-1H-benzimidazol-5-yl)-2-methyl- 4-bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-oxo-1H-benzimidazol-5-yl)-2-methyl-benzenesulfonamide |
| Description | OF-1 is a selective BRPF1B and BRPF2 bromodomain inhibitor with Kd values of 100 nM/500 nM for BRPF1B/BRPF2; 39-fold selectivity over BRD4. |
|---|---|
| Related Catalog |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 573.8±60.0 °C at 760 mmHg |
| Molecular Formula | C17H18BrN3O4S |
| Molecular Weight | 440.311 |
| Flash Point | 300.8±32.9 °C |
| Exact Mass | 439.020142 |
| PSA | 90.71000 |
| LogP | 3.32 |
| Appearance | white to beige |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.644 |
| Storage condition | 2-8°C |
| Water Solubility | DMSO: soluble5mg/mL, clear (warmed) |
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301-H319 |
| Precautionary Statements | P301 + P310-P305 + P351 + P338 |
| Hazard Codes | T,Xi |
| Risk Phrases | 25-36 |
| Safety Phrases | 26-45 |
| RIDADR | UN 2811 6.1 / PGIII |