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118-10-5

118-10-5 structure
118-10-5 structure
  • Name: Cinchonine
  • Chemical Name: cinchonine
  • CAS Number: 118-10-5
  • Molecular Formula: C19H22N2O
  • Molecular Weight: 294.39
  • Catalog: API Antiparasitic drug Antimalarial
  • Create Date: 2018-08-26 14:34:15
  • Modify Date: 2025-08-20 19:20:28
  • Cinchonine is a natural compound present in Cinchona bark. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells[1].
Name cinchonine
Synonyms (1S)-Quinolin-4-yl((2R,4S,5R)-5-vinylquinuclidin-2-yl)methanol
homoquinidine
MFCD00064372
EINECS 204-234-6
cinchonidine
chinchonine
Cinchonine
Cinchonan-9-ol, (8α,9S)-
D-CINCHONINE
Cinchonin
(8α,9S)-Cinchonan-9-ol
Description Cinchonine is a natural compound present in Cinchona bark. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells[1].
Related Catalog
References

[1]. Jin ZL, et al. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells. Exp Ther Med. 2018 Jun;15(6):5046-5050.
Density 1.2±0.1 g/cm3
Boiling Point 464.5±30.0 °C at 760 mmHg
Melting Point 260-263 °C
Molecular Formula C19H22N2O
Molecular Weight 294.39
Flash Point 234.7±24.6 °C
Exact Mass 294.173218
PSA 36.36000
LogP 3.35
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.652
Water Solubility Insoluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GD3500000
CHEMICAL NAME :
Cinchonine
CAS REGISTRY NUMBER :
118-10-5
LAST UPDATED :
199701
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C19-H22-N2-O
MOLECULAR WEIGHT :
294.43
WISWESSER LINE NOTATION :
T66 BNJ EYQ- DT66 A B CNTJ A1U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
152 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Behavioral - changes in motor activity (specific assay)
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 4,265,1948
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Cardiac - other changes Lungs, Thorax, or Respiration - respiratory depression Blood - other hemolysis with or without anemia
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 205,129,1948
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Amphibian - frog
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Blood - other hemolysis with or without anemia
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 205,129,1948
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H332
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn:Harmful
Risk Phrases R20/21/22
Safety Phrases S26-S36-S36/37
RIDADR 1544
WGK Germany 3
RTECS GD3500000
Packaging Group III
Hazard Class 6.1(b)
HS Code 2933990090
560119-43-9 structure

560119-43-9

~53%

118-10-5 structure

118-10-5

560119-45-1 structure

560119-45-1

Literature: Journal of Organic Chemistry, , vol. 69, # 9 p. 2983 - 2991
189309-24-8 structure

189309-24-8

~14%

1393446-38-2 structure

1393446-38-2

118-10-5 structure

118-10-5

118-10-5 structure

118-10-5

Literature: Arkivoc, , vol. 2012, # 6 p. 264 - 280
189309-24-8 structure

189309-24-8

~30%

1393446-38-2 structure

1393446-38-2

118-10-5 structure

118-10-5

Literature: Arkivoc, , vol. 2012, # 6 p. 264 - 280
189309-24-8 structure

189309-24-8

~%

118-10-5 structure

118-10-5

Literature: Bulletin des Societes Chimiques Belges, , vol. 106, # 2 p. 77 - 84
118-10-5 structure

118-10-5

~%

118-10-5 structure

118-10-5

Literature: Bulletin des Societes Chimiques Belges, , vol. 106, # 2 p. 77 - 84
118-10-5 structure

118-10-5

~%

1393446-38-2 structure

1393446-38-2

118-10-5 structure

118-10-5

Literature: Arkivoc, , vol. 2012, # 6 p. 264 - 280
71-41-0 structure

71-41-0

118-10-5 structure

118-10-5

~%

118-10-5 structure

118-10-5

485-71-2 structure

485-71-2

Detail
Literature: Justus Liebigs Annalen der Chemie, , vol. 492, p. 242,255
HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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