5334-30-5
5334-30-5 structure
- Name: PP3
- Chemical Name: 4-amino-1-phenylpyrazolo[3,4-d]pyrimidine
- CAS Number: 5334-30-5
- Molecular Formula: C11H9N5
- Molecular Weight: 211.223
- Catalog: Pharmaceutical intermediate Heterocyclic compound Pyrimidine compound Phenylpyrimidine
- Create Date: 2018-12-27 17:32:19
- Modify Date: 2025-08-21 01:07:37
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PP 3 (Compound 3) is an EGFR tyrosine kinase inhibitor with an IC50 of 2.7 μM[1].
| Name | 4-amino-1-phenylpyrazolo[3,4-d]pyrimidine |
|---|---|
| Synonyms |
1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-phenyl-
4-Amino-1-phenylpyrazolo[3,4-d]pyrimidine MFCD00022901 1-Phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine 1-phenylpyrazolo[3,4-d]pyrimidin-4-amine 4-Amino-1-phenylpyrazole[3,4-d]pyrimidine PP3 |
| Description | PP 3 (Compound 3) is an EGFR tyrosine kinase inhibitor with an IC50 of 2.7 μM[1]. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 364.0±35.0 °C at 760 mmHg |
| Melting Point | 214-217 °C |
| Molecular Formula | C11H9N5 |
| Molecular Weight | 211.223 |
| Flash Point | 173.9±25.9 °C |
| Exact Mass | 211.085800 |
| PSA | 69.62000 |
| LogP | 1.59 |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
| Index of Refraction | 1.770 |
| Storage condition | -20°C |
| Hazard Codes | Xn,Xi |
|---|---|
| Risk Phrases | R36/37/38 |
| Safety Phrases | S36/37/39-S26 |
| HS Code | 2933990090 |
|
~80%
5334-30-5 |
| Literature: Rahmouni, Ameur; Romdhane, Anis; Ben Said, Abderrahim; Majouli, Kaouther; Ben Jannet, Hichem Turkish Journal of Chemistry, 2014 , vol. 38, # 2 p. 210 - 221 |
|
~67%
5334-30-5 |
| Literature: Karoui, Amine; Allouche, Fatma; Deghrigue, Monia; Agrebi, Asma; Bouraoui, Abderrahman; Chabchoub, Fakher Medicinal Chemistry Research, 2014 , vol. 23, # 3 p. 1591 - 1598 |
|
~%
5334-30-5 |
| Literature: Journal of Organic Chemistry, , vol. 21, p. 1240,1242 |
|
~%
5334-30-5 |
| Literature: Journal of Organic Chemistry, , vol. 21, p. 1240,1242 |
|
~%
5334-30-5 |
| Literature: Medicinal Chemistry Research, , vol. 23, # 3 p. 1591 - 1598 |
| Precursor 5 | |
|---|---|
| DownStream 10 | |
![4H-Pyrazolo[3,4-d]pyrimidin-4-one,1,5-dihydro-1-phenyl- structure](https://image.chemsrc.com/caspic/003/21314-17-0.png)
![4-(4-chlorophenyl)-1-phenylpyrazolo[3,4-d]pyrimidine structure](https://image.chemsrc.com/caspic/489/87412-79-1.png)
![4-(2-chlorophenyl)-1-phenylpyrazolo[3,4-d]pyrimidine structure](https://image.chemsrc.com/caspic/027/87412-78-0.png)
![1,4-diphenylpyrazolo[3,4-d]pyrimidine structure](https://image.chemsrc.com/caspic/178/53645-78-6.png)
![4-(4-methoxyphenyl)-1-phenylpyrazolo[3,4-d]pyrimidine structure](https://image.chemsrc.com/caspic/113/87412-76-8.png)
![4-(2-methoxyphenyl)-1-phenylpyrazolo[3,4-d]pyrimidine structure](https://image.chemsrc.com/caspic/151/87412-75-7.png)
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |