Abstract We report the synthesis of new anti-inflammatory 1, 7-dihydropyrazolo [3′, 4′: 4, 5] pyrimido [1, 6-a] pyrimidine 5 from aminocyanopyrazole. All compounds were characterized by physical, chemical and spectral studies. Preliminary pharmacological evaluation of the resulting products showed that compounds 5a, b, f (50–100 mg/kg, ip) are active anti-inflammatory agents in carrageenan-induced rat paw oedema assay, and their ...