756875-51-1

756875-51-1 structure

Name: K6PC-5
Chemical Name: N-(1,3-dihydroxypropan-2-yl)-2-hexyl-3-oxodecanamide
CAS Number: 756875-51-1
Molecular Formula: C₁₉H₃₇NO₄
Molecular Weight: 343.50100
Catalog: Signaling Pathways Immunology/Inflammation SPHK
Create Date: 2017-06-03 14:39:55
Modify Date: 2024-01-08 10:05:07
K6PC-5, a synthetic ceramide derivative,is a direct sphingosine kinase 1(SPHK1) activator and elicites a rapid transient increase in intracellular calcium levels. K6PC-5 is used for the researches of skin diseases involving abnormal keratinocyte, neurodegeneration and virus infection[1][2][3].

Name	N-(1,3-dihydroxypropan-2-yl)-2-hexyl-3-oxodecanamide
Synonyms	UNII-9UO46U4GM1 Dihydroxyisopropyl capryloylcaprylamide K6PC-5

Description	K6PC-5, a synthetic ceramide derivative,is a direct sphingosine kinase 1(SPHK1) activator and elicites a rapid transient increase in intracellular calcium levels. K6PC-5 is used for the researches of skin diseases involving abnormal keratinocyte, neurodegeneration and virus infection[1][2][3].
Related Catalog	Research Areas >> Infection Research Areas >> Neurological Disease Signaling Pathways >> Immunology/Inflammation >> SPHK
References	[1]. Kwon YB, et al. Novel synthetic ceramide derivatives increase intracellular calcium levels and promote epidermal keratinocyte differentiation. J Lipid Res. 2007 Sep;48(9):1936-43. [2]. Di Pardo A, et al. Treatment with K6PC-5, a selective stimulator of SPHK1, ameliorates intestinal homeostasis in an animal model of Huntington's disease. Neurobiol Dis. 2020 Sep;143:105009. [3]. Imre G, et al. The sphingosine kinase 1 activator, K6PC-5, attenuates Ebola virus infection. iScience. 2021 Mar 5;24(4):102266.

Hazard Codes	Xi