20724-73-6

20724-73-6 structure

Name: 2'-C-Methylcytidine
Chemical Name: 4-amino-1-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]pyrimidin-2-one
CAS Number: 20724-73-6
Molecular Formula: C₁₀H₁₅N₃O₅
Molecular Weight: 257.243
Catalog: Biochemical Nucleoside drugs Nucleoside intermediate
Create Date: 2018-07-06 19:57:10
Modify Date: 2024-01-02 22:59:04
NM107 is a inhibitors of HCV RNA replication with IC50 of 7.0 μM in vitro.IC50 value: 7.0 μMTarget:HCV RNA replicationNM107 is a potent and selective inhibitor of flavi- and pesti-virus replication in cell culture, with inhibitory activity and cytotoxicity against HCV 1b replicon cells, IC50 is 1.13 μM. Intracellular HCV RNA in HCV-infected cells treated the HCV polymerase inhibitor NM107 shows a similar pattern of decline. NM107 are currently being investigated as additional therapeutic agents for HCV infection. NM107 inhibits bovine viral diarrhea virus (BVDV) replication (EC50 0.67 nM), eliminates persistent BVDV infection at nontoxic concentrations.

Name	4-amino-1-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]pyrimidin-2-one
Synonyms	valopicitabine 2-C-METHYLCYTIDINE 2'-C-Methyl Cytidine Cytidine,2'-C-methyl 2'-METHYLCYTIDINE NM107 Cytidine, 2'-C-methyl- UNII-27FS20C1D8 1-((2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)-4-aminopyrimidin-2(1H)-one UNII:27FS20C1D8 2'-C-methylcytidine

Description	NM107 is a inhibitors of HCV RNA replication with IC50 of 7.0 μM in vitro.IC50 value: 7.0 μMTarget:HCV RNA replicationNM107 is a potent and selective inhibitor of flavi- and pesti-virus replication in cell culture, with inhibitory activity and cytotoxicity against HCV 1b replicon cells, IC50 is 1.13 μM. Intracellular HCV RNA in HCV-infected cells treated the HCV polymerase inhibitor NM107 shows a similar pattern of decline. NM107 are currently being investigated as additional therapeutic agents for HCV infection. NM107 inhibits bovine viral diarrhea virus (BVDV) replication (EC50 0.67 nM), eliminates persistent BVDV infection at nontoxic concentrations.
Related Catalog	Signaling Pathways >> Anti-infection >> HCV Research Areas >> Infection
References	[1]. McCown MF, et al. The hepatitis C virus replicon presents a higher barrier to resistance to nucleoside analogs than to nonnucleosidepolymerase or protease inhibitors. Antimicrob Agents Chemother. 2008 May;52(5):1604-1612.

Density	1.7±0.1 g/cm3
Boiling Point	523.9±60.0 °C at 760 mmHg
Melting Point	243-245ºC
Molecular Formula	C₁₀H₁₅N₃O₅
Molecular Weight	257.243
Flash Point	270.7±32.9 °C
Exact Mass	257.101166
PSA	130.83000
LogP	-0.80
Vapour Pressure	0.0±3.1 mmHg at 25°C
Index of Refraction	1.700
Storage condition	Hygroscopic, -20°C Freezer, Under Inert Atmosphere
Water Solubility	H2O: >20mg/mL

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Hazard Codes	Xi
Risk Phrases	36/37/38
Safety Phrases	26
RIDADR	NONH for all modes of transport
HS Code	2934999090

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%