80880-90-6
80880-90-6 structure
- Name: TELENZEPINE 2HCL
- Chemical Name: 1-methyl-10-[2-(4-methylpiperazin-1-yl)acetyl]-5H-thieno[3,4-b][1,5]benzodiazepin-4-one
- CAS Number: 80880-90-6
- Molecular Formula: C19H22N4O2S
- Molecular Weight: 370.46900
- Catalog: Signaling Pathways GPCR/G Protein mAChR
- Create Date: 2016-04-13 18:05:52
- Modify Date: 2024-01-14 17:59:38
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Telenzepine is an antimuscarinic agent with Kis of 0.94 nM (M1 mAChR) and 17.8 nM (M2 mAChR) binding to muscarinic receptors. Telenzepine effectively blocks synaptic transmission promoted by muscarinic or M1 receptor agonists. Thus, Telenzepine can reduce the amplitude of extracellular slow excitatory postsynaptic potentials (EC50=38 nM) and slow inhibitory postsynaptic potentials (EC50=253 nM)[1].
| Name | 1-methyl-10-[2-(4-methylpiperazin-1-yl)acetyl]-5H-thieno[3,4-b][1,5]benzodiazepin-4-one |
|---|---|
| Synonyms |
[3H]-(+/-)-Telenzepine
Telenzepino [Spanish] Telenzepine [INN] (+/-)-Telenzepine 9,10-dihydro-3-methyl-4-[(4-methylpiperazin-1-yl)acetyl]-4H-thieno[3,4-b][1,5]benzodiazepin-10-one 4,9-dihydro-3-methyl-4-[(4-methyl-1-piperazinyl)acetyl]-10H-thieno[3,4-b][1,5]benzodiazepin-10-one Telenzepinum [Latin] |
| Description | Telenzepine is an antimuscarinic agent with Kis of 0.94 nM (M1 mAChR) and 17.8 nM (M2 mAChR) binding to muscarinic receptors. Telenzepine effectively blocks synaptic transmission promoted by muscarinic or M1 receptor agonists. Thus, Telenzepine can reduce the amplitude of extracellular slow excitatory postsynaptic potentials (EC50=38 nM) and slow inhibitory postsynaptic potentials (EC50=253 nM)[1]. |
|---|---|
| Related Catalog | |
| References |
[1]. Telenzepine. IMGT. |
| Density | 1.281g/cm3 |
|---|---|
| Boiling Point | 544.7ºC at 760 mmHg |
| Molecular Formula | C19H22N4O2S |
| Molecular Weight | 370.46900 |
| Flash Point | 283.2ºC |
| Exact Mass | 370.14600 |
| PSA | 87.62000 |
| LogP | 2.29470 |
|
~%
80880-90-6 |
| Literature: BYK Gulden Lomberg Chemische Fabrik GmbH Patent: US5140025 A1, 1992 ; |
