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94-24-6

94-24-6 structure
94-24-6 structure
Name tetracaine
Synonyms Benzoic acid, 4-(butylamino)-, 2-(dimethylamino)ethyl ester
Tetracaina
Tetrakain
Anetain
EINECS 202-316-6
Pontocaine
Dicaine
Contralgin
2-(Dimethylamino)ethyl-4-(butylamino)benzolcarboxylat
Tetracainum
dicaine base
MFCD00053787
Amethocaine
2-(Dimethylamino)ethyl 4-(butylamino)benzoate
Uromucaesthin
Tetracaine
Description Tetracaine is a topical local anesthetic for the eyes; works by interfering with entry of sodium ions into nerve cells.
Related Catalog
Density 1.0±0.1 g/cm3
Boiling Point 389.4±27.0 °C at 760 mmHg
Melting Point 43 °C
Molecular Formula C15H24N2O2
Molecular Weight 264.363
Flash Point 189.3±23.7 °C
Exact Mass 264.183777
PSA 41.57000
LogP 3.65
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.538

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DG4725000
CHEMICAL NAME :
Benzoic acid, p-(butylamino)-, 2-(dimethylamino)ethyl ester
CAS REGISTRY NUMBER :
94-24-6
BEILSTEIN REFERENCE NO. :
2216051
LAST UPDATED :
199612
DATA ITEMS CITED :
19
MOLECULAR FORMULA :
C15-H24-N2-O2
MOLECULAR WEIGHT :
264.41
WISWESSER LINE NOTATION :
4MR DVO2N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
1 mg/kg
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity Behavioral - coma Lungs, Thorax, or Respiration - cyanosis
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
33 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intratracheal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
20 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
41500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
20 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
6 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
33500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intratracheal
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
6500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraspinal
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
4900 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Amphibian - frog
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Cardiac - other changes Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraspinal
SPECIES OBSERVED :
Amphibian - frog
DOSE/DURATION :
20 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Unscheduled DNA synthesis
TEST SYSTEM :
Human HeLa cell
DOSE/DURATION :
1 umol/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 14,205,1965 *** REVIEWS *** TOXICOLOGY REVIEW PHREA7 Physiological Reviews. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1921- Volume(issue)/page/year: 12,190,1932 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2779 No. of Facilities: 737 (estimated) No. of Industries: 3 No. of Occupations: 11 No. of Employees: 18810 (estimated) No. of Female Employees: 13703 (estimated)
Symbol GHS06 GHS08
GHS06, GHS08
Signal Word Danger
Hazard Statements H301-H317-H351
Precautionary Statements P280-P301 + P310
Hazard Codes Xn:Harmful;
Risk Phrases R22;R40;R42/43
Safety Phrases S22-S36/37
RIDADR UN 2811
RTECS DG4725000
HS Code 2922499990
108-01-0 structure

108-01-0

99-77-4 structure

99-77-4

123-72-8 structure

123-72-8

~94%

94-24-6 structure

94-24-6

Literature: Abdullaev Pharmaceutical Chemistry Journal, 2002 , vol. 36, # 1 p. 28 - 31
108-01-0 structure

108-01-0

4740-24-3 structure

4740-24-3

~%

94-24-6 structure

94-24-6

Literature: Journal of the Society of Chemical Industry, London, , vol. 64, p. 177 US1889645 , ; DE582715 , ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 19, p. 1536
94-09-7 structure

94-09-7

~%

94-24-6 structure

94-24-6

Literature: Journal of the Society of Chemical Industry, London, , vol. 64, p. 177
108-01-0 structure

108-01-0

94-32-6 structure

94-32-6

~%

94-24-6 structure

94-24-6

Literature: Journal of the Society of Chemical Industry, London, , vol. 64, p. 177 US1889645 , ; DE582715 , ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 19, p. 1536
4740-24-3 structure

4740-24-3

~%

94-24-6 structure

94-24-6

Literature: US1889645 , ;
109-65-9 structure

109-65-9

10012-47-2 structure

10012-47-2

~%

94-24-6 structure

94-24-6

Literature: US1889645 , ; DE582715 , ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 19, p. 1536
94-32-6 structure

94-32-6

~%

94-24-6 structure

94-24-6

Literature: Journal of the Society of Chemical Industry, London, , vol. 64, p. 177
HS Code 2922499990
Summary HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%
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