618-27-9

618-27-9 structure

Name: cis-4-hydroxy-L-proline
Chemical Name: cis-4-hydroxy-L-proline
CAS Number: 618-27-9
Molecular Formula: C₅H₉NO₃
Molecular Weight: 131.130
Catalog: Biochemical Amino acids and their derivatives Proline derivatives
Create Date: 2018-09-27 18:02:40
Modify Date: 2025-08-21 12:27:25
cis-4-Hydroxy-L-proline, a proline analogue, is an inhibitor of collagen production. cis-4-Hydroxy-L-proline could inhibit fibroblast growth by preventing the deposition of triple-helical collagen on the cell layer. cis-4-Hydroxy-L-proline also depresses the growth of primary N-nitrosomethylurea-induced rat mammary tumors[1][2][3][4].

Name	cis-4-hydroxy-L-proline
Synonyms	D-Proline, 4-hydroxy-, (4R)- (2S,4S)-4-hydroxypyrrolidine-2-carboxylic acid cis-4-Hydroxy-L-proline (4R)-4-Hydroxy-D-proline cis-4-Hydroxyproline MFCD00064319 (4S)-4-Hydroxy-L-prolin cis-4-Hydroxy-D-proline EINECS 210-542-1

Description	cis-4-Hydroxy-L-proline, a proline analogue, is an inhibitor of collagen production. cis-4-Hydroxy-L-proline could inhibit fibroblast growth by preventing the deposition of triple-helical collagen on the cell layer. cis-4-Hydroxy-L-proline also depresses the growth of primary N-nitrosomethylurea-induced rat mammary tumors[1][2][3][4].
Related Catalog	Research Areas >> Cancer Research Areas >> Metabolic Disease
References	[1]. Lewko WM, et, al. Sensitivity of N-nitrosomethylurea-induced rat mammary tumors to cis-hydroxyproline, an inhibitor of collagen production. Cancer Res. 1981 Jul;41(7):2855-62. [2]. Kao WW, et, al. Proline analogue removes fibroblasts from cultured mixed cell populations. Nature. 1977 Mar 3;266(5597):63-4. [3]. Tan EM, et, al. Proline analogues inhibit human skin fibroblast growth and collagen production in culture. J Invest Dermatol. 1983 Apr;80(4):261-7. [4]. Riley DJ, et, al. Prevention of bleomycin-induced pulmonary fibrosis in the hamster by cis-4-hydroxy-l-proline. Am Rev Respir Dis. 1981 Apr;123(4 Pt 1):388-93.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%