5184-64-5

5184-64-5 structure

Name: ESI 05
Chemical Name: 1,3,5-trimethyl-2-(4-methylphenyl)sulfonylbenzene
CAS Number: 5184-64-5
Molecular Formula: C₁₆H₁₈O₂S
Molecular Weight: 274.37800
Catalog: Research Areas Others
Create Date: 2016-12-18 06:41:12
Modify Date: 2024-01-11 20:18:50
ESI-05 (NSC 116966) is a specific exchange protein directly activated by cAMP 2 (EPAC2) antagonist (IC50, 0.4 µM), suppresses the cAMP-mediated activation of EPAC2 and inhibits Rap1 activation mediated by EAPC2[1].

Name	1,3,5-trimethyl-2-(4-methylphenyl)sulfonylbenzene
Synonyms	mesityl(4-methylphenyl) sulfone

Description	ESI-05 (NSC 116966) is a specific exchange protein directly activated by cAMP 2 (EPAC2) antagonist (IC50, 0.4 µM), suppresses the cAMP-mediated activation of EPAC2 and inhibits Rap1 activation mediated by EAPC2[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
Target	IC50: 0.4 µM (EPAC2)[1]
References	[1]. Tsalkova T, et al. Isoform-specific antagonists of exchange proteins directly activated by cAMP. Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18613-8.