110953-39-4

110953-39-4 structure
110953-39-4 structure
  • Name: 3-Methyladenine-d3
  • Chemical Name: 3-(trideuteriomethyl)purin-6-amine
  • CAS Number: 110953-39-4
  • Molecular Formula: C6H4D3N5
  • Molecular Weight: 152.17200
  • Catalog: Signaling Pathways Autophagy Autophagy
  • Create Date: 2017-04-26 03:42:59
  • Modify Date: 2024-03-03 13:47:14
  • 3-Methyladenine-d3 is the deuterium labeled 3-Methyladenine[1]. 3-Methyladenine (3-MA) is a PI3K inhibitor. 3-Methyladenine is a widely used inhibitor of autophagy via its inhibitory effect on class III PI3K[2].

Name 3-(trideuteriomethyl)purin-6-amine
Synonyms 3-(Methyl-d3)-6-aminopurine
N3-(Methyl-d3)adenine
3-Methyl Adenine-d3
3-Methyl-d3-adenine
6-Amino-3-(methyl-d3)purine
3-(Methyl-d3)-3H-purin-6-amine
Description 3-Methyladenine-d3 is the deuterium labeled 3-Methyladenine[1]. 3-Methyladenine (3-MA) is a PI3K inhibitor. 3-Methyladenine is a widely used inhibitor of autophagy via its inhibitory effect on class III PI3K[2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Miller S, et al. Finding a fitting shoe for Cinderella: searching for an autophagy inhibitor. Autophagy. 2010 Aug;6(6):805-7.  

[3]. Hou H, et al. Inhibitors of phosphatidylinositol 3'-kinases promote mitotic cell death in HeLa cells. PLoS One. 20127(4):e35665.  

[4]. Wang X, et al. Acanthopanax versus 3-Methyladenine Ameliorates Sodium Taurocholate-Induced Severe Acute Pancreatitis by Inhibiting the Autophagic Pathway in Rats.Mediators Inflamm. 20162016:8369704.  

Molecular Formula C6H4D3N5
Molecular Weight 152.17200
Exact Mass 152.08900
PSA 69.62000
LogP 0.52670