143322-58-1

143322-58-1 structure

Name: Eletriptan
Chemical Name: eletriptan
CAS Number: 143322-58-1
Molecular Formula: C₂₂H₂₆N₂O₂S
Molecular Weight: 382.519
Catalog: API Antipyretic analgesics Analgesic
Create Date: 2018-02-23 08:00:00
Modify Date: 2024-01-02 18:26:48
Eletriptan (UK-116044) is a highly selective and orally active serotonin 5-HT1B and 5-HT1D receptor agonist, with pKi values of 8.0 and 8.9, respectively. Eletriptan has inhibitory effects on markers of neurogenic inflammation in rats. Eletriptan can be used for researching migraine[1].

Name	eletriptan
Synonyms	3-{[(2R)-1-Methylpyrrolidin-2-yl]methyl}-5-[2-(phenylsulfonyl)ethyl]-1H-indole 3-{[(2R)-1-Methyl-2-pyrrolidinyl]methyl}-5-[2-(phenylsulfonyl)ethyl]-1H-indole Eletriptan MFCD00943792 1H-Indole, 3-[[(2R)-1-methyl-2-pyrrolidinyl]methyl]-5-[2-(phenylsulfonyl)ethyl]- 5-[2-(benzenesulfonyl)ethyl]-3-[[(2R)-1-methylpyrrolidin-2-yl]methyl]-1H-indole

Description	Eletriptan (UK-116044) is a highly selective and orally active serotonin 5-HT1B and 5-HT1D receptor agonist, with pKi values of 8.0 and 8.9, respectively. Eletriptan has inhibitory effects on markers of neurogenic inflammation in rats. Eletriptan can be used for researching migraine[1].
Related Catalog	Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	5-HT1B Receptor:8.0 (pKi) 5-HT1D Receptor:8.9 (pKi)
In Vivo	Eletriptan (10, 30, 100, 300 and 1000 µg/kg; i.v.) reduces total carotid blood flow in anaesthetised pigs by selectively reducing carotid arteriovenous anastomotic blood flow and increasing nutrient blood flow within the carotid vascular bed[2].
References	[1]. McCormack PL, Keating GM. Eletriptan: a review of its use in the acute treatment of migraine. Drugs. 2006;66(8):1129-49. [2]. Willems E, et al. Porcine carotid vascular effects of eletriptan (UK-116,044): a new 5-HT1B/1D receptor agonist with anti-migraine activity. Naunyn Schmiedebergs Arch Pharmacol. 1998 Aug;358(2):212-9.

Density	1.2±0.1 g/cm3
Boiling Point	613.4±55.0 °C at 760 mmHg
Molecular Formula	C₂₂H₂₆N₂O₂S
Molecular Weight	382.519
Flash Point	324.8±31.5 °C
Exact Mass	382.171509
PSA	61.55000
LogP	3.08
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.634
Storage condition	Hygroscopic, Refrigerator, Under Inert Atmosphere