917567-60-3

917567-60-3 structure

Name: PSB 0474
Chemical Name: PSB 0474,3-(2-Oxo-2-phenylethyl)-uridine-5'-diphosphatedisodiumsalt
CAS Number: 917567-60-3
Molecular Formula: C₁₇H₂₀N₂O₁₃P₂
Molecular Weight: 522.29
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2017-10-31 20:11:50
Modify Date: 2025-08-26 12:19:34
PSB 0474 (3-phenacyl-UDP) is a selective and potent P2Y6 receptor agonist with an EC50 of 70 nM[1]. PSB 0474 inhibits cell proliferation, increases NO release in astrocytes and microglia cells. PSB 0474 induces astrocytes apoptosis[2].

Name	PSB 0474,3-(2-Oxo-2-phenylethyl)-uridine-5'-diphosphatedisodiumsalt
Synonyms	3-phenacyl udp disodium salt psb 0474

Description	PSB 0474 (3-phenacyl-UDP) is a selective and potent P2Y6 receptor agonist with an EC50 of 70 nM[1]. PSB 0474 inhibits cell proliferation, increases NO release in astrocytes and microglia cells. PSB 0474 induces astrocytes apoptosis[2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Signaling Pathways >> GPCR/G Protein >> P2Y Receptor Research Areas >> Neurological Disease
Target	IC50: 70 nM (P2Y6)[1]
References	[1]. Ali El-Tayeb, et al. Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4, and P2Y6 receptors. J Med Chem. 2006 Nov 30;49(24):7076-87. [2]. Clara Quintas, et al. Microglia P2Y₆ receptors mediate nitric oxide release and astrocyte apoptosis. J Neuroinflammation. 2014 Sep 3;11:141.