DC Chemicals Limited
China
Product Name: Indolactam V
Price: $Inquiry/25mg $155.0/1mg $425.0/5mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (-)-ETHYL(S)-3-HYDROXY-3-PHENYLPROPIONATE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

90365-57-4

90365-57-4 structure

Name: (-)-Indolactam V
Chemical Name: (-)-Indolactam V,(2S,5S)-1,2,4,5,6,8-Hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-3H-pyrrolo[4,3,2-gh]-1,4-benzodiazonin-3-one
CAS Number: 90365-57-4
Molecular Formula: C₁₇H₂₃N₃O₂
Molecular Weight: 301.383
Catalog: Research Areas Cancer
Create Date: 2017-02-03 05:37:51
Modify Date: 2024-01-03 11:14:58
(-)-Indolactam V is a PKC activator, with Kis of 3.36 nM, 1.03 μM for η-CRD2 (PKCη surrogate peptide), γ-CRD2 (PKCγ surrogate peptide), and Kds of 5.5 nM (η-C1B), 7.7 nM (ε-C1B), 8.3 nM (δ-C1B), 18.9 nM (β-C1A-long), 20.8 nM (α-C1A-long), 137 nM (β-C1B), 138 nM (γ-C1A), 213 nM (γ-C1B), and has antitumor activity.

Name	(-)-Indolactam V,(2S,5S)-1,2,4,5,6,8-Hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-3H-pyrrolo[4,3,2-gh]-1,4-benzodiazonin-3-one
Synonyms	(2S,5S)-5-(hydroxymethyl)-1-methyl-2-(propan-2-yl)-1,2,4,5,6,8-hexahydro-3H-[1,4]diazonino[7,6,5-cd]indol-3-one 3H-1,4-Diazonino[7,6,5-cd]indol-3-one, 1,2,4,5,6,8-hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-, (2S,5S)- (-)-indolactam Indolactam V (2S,5S)-5-(Hydroxymethyl)-2-isopropyl-1-methyl-1,2,4,5,6,8-hexahydro-3H-[1,4]diazonino[7,6,5-cd]indol-3-one

Description	(-)-Indolactam V is a PKC activator, with Kis of 3.36 nM, 1.03 μM for η-CRD2 (PKCη surrogate peptide), γ-CRD2 (PKCγ surrogate peptide), and Kds of 5.5 nM (η-C1B), 7.7 nM (ε-C1B), 8.3 nM (δ-C1B), 18.9 nM (β-C1A-long), 20.8 nM (α-C1A-long), 137 nM (β-C1B), 138 nM (γ-C1A), 213 nM (γ-C1B), and has antitumor activity.
Related Catalog	Research Areas >> Cancer
Target	PKCη-CRD2:3.36 nM (Ki) PKCη-C1B:5.5 nM (Kd) PKCε-C1B:7.7 nM (Kd) PKCδ-C1B:8.3 nM (Kd) PKCθ-C1B:8.7 nM (Kd) PKCβ-C1A-long:18.9 nM (Kd) PKCα-C1A-long:20.8 nM (Kd) PKCβ-C1B:137 nM (Kd) PKCγ-C1A:138 nM (Kd) PKCγ-C1B:213 nM (Kd) PKCγ-CRD2:1030 nM (Ki) PKCδ-C1A:1900 nM (Kd) PKCη-C1A:3770 nM (Kd) PKCα-C1B-long:4000 nM (Kd) PKCε-C1A:4110 nM (Kd)
In Vitro	(-)-Indolactam V is a PKC activator, with Kis of 3.36 nM, 1.03 μM for η-CRD2 (PKCη surrogate peptide), γ-CRD2 (PKCγ surrogate peptide), and has antitumor activity[1]. (-)-Indolactam V shows Kds of 5.5 nM (η-C1B), 7.7 nM (ε-C1B), 8.3 nM (δ-C1B), 18.9 nM (β-C1A-long), 20.8 nM (α-C1A-long), 137 nM (β-C1B), 138 nM (γ-C1A), 213 nM (γ-C1B), respectively[2]. (-)-Indolactam V (20 nM-5 μM) dose-dependently affects multiple hESC lines, such as HUES 2, 4 and 8. (-)-Indolactam V also increases the mRNA levels of Pdx1, HNF6, PTF1A, SOX9, HB9 and PROX1. In addition, (-)-Indolactam V (300 nM) functions in both mouse and human cells and confirms that some signals for pancreatic development[3].
Cell Assay	For induced differentiation to endocrine or exocrine cells, the (-)-Indolactam V (300 nM)-treated populations are cultured in DMEM/F12 supplemented with 1 N2, 2 mg/mL albumin fraction V and 10 ng/mL bovine FGF for the first 4 d. 10 mM nicotinamide is then added and maintained for an additional 8 d, changing the medium every 3 d[3].
References	[1]. Nakagawa Y, et al. Synthesis and biological activities of indolactone-V, the lactone analogue of the tumor promoter (-)-indolactam-V. Biosci Biotechnol Biochem. 1997 Aug;61(8):1415-7. [2]. Masuda A, et al. Binding selectivity of conformationally restricted analogues of (-)-indolactam-V to the C1 domains of protein kinase C isozymes. Biosci Biotechnol Biochem. 2002 Jul;66(7):1615-7. [3]. Chen S, et al. A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat Chem Biol. 2009 Apr;5(4):258-65.

Density	1.2±0.1 g/cm3
Boiling Point	584.0±50.0 °C at 760 mmHg
Molecular Formula	C₁₇H₂₃N₃O₂
Molecular Weight	301.383
Flash Point	307.0±30.1 °C
Exact Mass	301.179016
PSA	68.36000
LogP	0.75
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.590

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UY8547000

CHEMICAL NAME :: 3H-Pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one, 1,2,4,5,6,8-hexahydro-5-(hydroxymethyl)-1- methyl-2-(1-methylethyl)-, (2S-(2R*,5R*))-

CAS REGISTRY NUMBER :: 90365-57-4

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C17-H23-N3-O2

MOLECULAR WEIGHT :: 301.43

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1250 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 44,1029,1991

RIDADR	NONH for all modes of transport

90365-57-4	121706-11-4
90365-56-3	132738-83-1
21773-34-2	52940-42-8
16017-37-1	4479-11-2
132097-01-9	77263-11-7