868359-05-1

868359-05-1 structure

Name: WAY 213613
Chemical Name: (2S)-2-amino-4-[4-(2-bromo-4,5-difluorophenoxy)anilino]-4-oxobutanoic acid
CAS Number: 868359-05-1
Molecular Formula: C₁₆H₁₃BrF₂N₂O₄
Molecular Weight: 415.19
Catalog: Signaling Pathways Membrane Transporter/Ion Channel EAAT2
Create Date: 2016-03-15 06:41:46
Modify Date: 2024-03-07 16:43:18
WAY-213613 is a potent, selective human EAAT2 inhibitor (IC50, 85 nM), exhibits 59- and 45-fold selectivity over human EAAT1 and EAAT3. Inhibits glutamate uptake in rat cortical synaptosomes[1].

Name	(2S)-2-amino-4-[4-(2-bromo-4,5-difluorophenoxy)anilino]-4-oxobutanoic acid
Synonyms	way-213,613

Description	WAY-213613 is a potent, selective human EAAT2 inhibitor (IC50, 85 nM), exhibits 59- and 45-fold selectivity over human EAAT1 and EAAT3. Inhibits glutamate uptake in rat cortical synaptosomes[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> EAAT2 Research Areas >> Neurological Disease
Target	IC50: 85 nM (Human EAAT2), 3.8 μM (Human EAAT3), 5 μM (Human EAAT1)[1]
In Vitro	WAY-213613 exhibits IC50s of 5 and 3.8 μM for EAAT1 and EAAT3, respectively[1].
References	[1]. Dunlop J, et al. Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT2. Mol Pharmacol. 2005 Oct;68(4):974-82. Epub 2005 Jul 13.