Top Suppliers:I want be here
Related CAS#:
56776-32-0 1406-14-0
6138-79-0 186694-02-0
1334385-87-3 929-73-7
127228-87-9 143851-98-3
56-99-5 1406-02-6

56776-32-0

56776-32-0 structure
56776-32-0 structure
  • Name: Etifoxine hydrochloride
  • Chemical Name: Etifoxine Hydrochloride
  • CAS Number: 56776-32-0
  • Molecular Formula: C17H18Cl2N2O
  • Molecular Weight: 337.244
  • Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
  • Create Date: 2018-12-04 19:54:11
  • Modify Date: 2024-01-02 16:11:49
  • Etifoxine Hcl(HOE 36-801) is potentiator of GABAA receptor function in cultured neurons. Etifoxine preferentially acts on β2 or β3 subunit-containing GABAA receptors. IC50 value:Target: GABAA receptorEtifoxine exhibits anxiolytic activity in rodents and humans with no sedative, myorelaxant or mnesic side effects. Etifoxine acts as a ligand of the translocator protein (TSPO); promotes axonal regeneration.
Name Etifoxine Hydrochloride
Synonyms 6-Chloro-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine hydrochloride (1:1)
4H-3,1-Benzoxazin-2-amine, 6-chloro-N-ethyl-4-methyl-4-phenyl-, hydrochloride (1:1)
6-chloro-N-ethyl-4-methyl-4-phenyl-3,1-benzoxazin-2-amine,hydrochloride
4H-3,1-Benzoxazin-2-amine, 6-chloro-N-ethyl-4-methyl-4-phenyl-, monohydrochloride
Etifoxine (hydrochloride)
Description Etifoxine Hcl(HOE 36-801) is potentiator of GABAA receptor function in cultured neurons. Etifoxine preferentially acts on β2 or β3 subunit-containing GABAA receptors. IC50 value:Target: GABAA receptorEtifoxine exhibits anxiolytic activity in rodents and humans with no sedative, myorelaxant or mnesic side effects. Etifoxine acts as a ligand of the translocator protein (TSPO); promotes axonal regeneration.
Related Catalog
References

[1]. Verleye M, Dumas S, Heulard I, et al. Differential effects of etifoxine on anxiety-like behaviour and convulsions in BALB/cByJ and C57BL/6J mice: any relation to overexpression of central GABAA receptor beta2 subunits? Eur Neuropsychopharmacol. 2011 Jun;2

[2]. Bourin M, Hascot M. Implication of 5-HT2 receptor subtypes in the mechanism of action of the GABAergic compound etifoxine in the four-plate test in Swiss mice. Behav Brain Res. 2010 Apr 2;208(2):352-8.

[3]. Gee KW, Tran MB, Hogenkamp DJ, et al. Limiting activity at beta1-subunit-containing GABAA receptor subtypes reduces ataxia. J Pharmacol Exp Ther. 2010 Mar;332(3):1040-53.

[4]. Aouad M, Charlet A, Rodeau JL, et al. Reduction and prevention of vincristine-induced neuropathic pain symptoms by the non-benzodiazepine anxiolytic etifoxine are mediated by 3alpha-reduced neurosteroids. Pain. 2009 Dec 15;147(1-3):54-9.

[5]. Girard C, Liu S, Cadepond F, et al. Etifoxine improves peripheral nerve regeneration and functional recovery. Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20505-10.
Density 1.2g/cm3
Boiling Point 421.2ºC at 760mmHg
Molecular Formula C17H18Cl2N2O
Molecular Weight 337.244
Flash Point 208.5ºC
Exact Mass 336.079620
PSA 33.62000
LogP 4.85920
Storage condition 2-8℃
RIDADR NONH for all modes of transport

Chemsrc provides CAS#:56776-32-0 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 56776-32-0 | Chemsrc address: https://www.chemsrc.com/en/baike/754115.html

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved