121346-32-5
121346-32-5 structure
- Name: SR-33805
- Chemical Name: SR 33805 oxalate,3,4-Dimethoxy-N-methyl-N-[3-[4-[[1-methyl-3-(1-methylethyl)-1H-indol-2-yl]sulfonyl]phenoxy]propyl]benzeneethanamine
- CAS Number: 121346-32-5
- Molecular Formula: C34H42N2O9S
- Molecular Weight: 654.77000
- Create Date: 2018-10-20 13:27:56
- Modify Date: 2025-09-18 07:00:06
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SR-33805 is a calcium channel antagonist potentially for the treatment of atherosclerosis and heart failure. SR-33805 restored the MI-altered cell shortening without affecting the Ca(2+) transient amplitude, suggesting an increase of myofilament Ca(2+) sensitivity in MI myocytes. A SR33805-induced sensitization of myofilament activation was found to be associated with a slight increase in myosin light chain-2 phosphorylation and a more significant decrease on troponin I (TnI) phosphorylation. Decreased TnI phosphorylation was related to inhibition of protein kinase A activity by SR-33805.
| Name | SR 33805 oxalate,3,4-Dimethoxy-N-methyl-N-[3-[4-[[1-methyl-3-(1-methylethyl)-1H-indol-2-yl]sulfonyl]phenoxy]propyl]benzeneethanamine |
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| Boiling Point | 728.7ºC at 760 mmHg |
|---|---|
| Molecular Formula | C34H42N2O9S |
| Molecular Weight | 654.77000 |
| Flash Point | 394.5ºC |
| Exact Mass | 654.26100 |
| PSA | 152.98000 |
| LogP | 6.33150 |
| Vapour Pressure | 4.34E-21mmHg at 25°C |
| Hazard Codes | Xi |
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