105956-99-8

105956-99-8 structure

Name: clinafloxacin hydrochloride
Chemical Name: Clinafloxacin Hydrochloride
CAS Number: 105956-99-8
Molecular Formula: C₁₇H₁₈Cl₂FN₃O₃
Molecular Weight: 402.247
Catalog: API Synthetic anti-infective drugs Quinolone
Create Date: 2018-08-25 12:45:18
Modify Date: 2024-01-02 18:25:35
Clinafloxacin hydrochloride (AM 1091 hydrochloride) is a potent and broad-spectrum fluoroquinolone antibiotic, with activity against gram-positive, gram-negative, and anaerobic pathogens in vitro. Clinafloxacin exhibits activity against S. pneumonia with an MIC of 1μg/ml for the parC-gyrA mutants[1][2].

Name	Clinafloxacin Hydrochloride
Synonyms	7-(3-aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylic acid,hydrochloride 7-(3-Aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride (1:1) 7-(3-Amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid hydrochloride (1:1) 3-Quinolinecarboxylic acid, 7-(3-amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-, hydrochloride (1:1) Clinafloxacin HCl clinafloxacin hydrochloride

Description	Clinafloxacin hydrochloride (AM 1091 hydrochloride) is a potent and broad-spectrum fluoroquinolone antibiotic, with activity against gram-positive, gram-negative, and anaerobic pathogens in vitro. Clinafloxacin exhibits activity against S. pneumonia with an MIC of 1μg/ml for the parC-gyrA mutants[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	MIC: 1μg/ml (parC-gyrA mutants,S. pneumonia)[1]
References	[1]. Pan, X.S. and L.M. Fisher, DNA gyrase and topoisomerase IV are dual targets of clinafloxacin action in Streptococcus pneumoniae. Antimicrob Agents Chemother, 1998. 42(11): p. 2810-6. [2]. Jorgensen, J.H., et al., Activities of clinafloxacin, gatifloxacin, gemifloxacin, and trovafloxacin against recent clinical isolates of levofloxacin-resistant Streptococcus pneumoniae. Antimicrob Agents Chemother, 2000. 44(11): p. 2962-8.