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Dayang Chem (Hangzhou) Co., Ltd.
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Zhejiang Hangyu API Co., Ltd
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66230-04-4

66230-04-4 structure

Name: Esfenvalerate
Chemical Name: Esfenvalerate
CAS Number: 66230-04-4
Molecular Formula: C₂₅H₂₂ClNO₃
Molecular Weight: 419.900
Catalog: Chemical pesticide Insecticide Pyrethroid insecticide
Create Date: 2018-08-20 11:17:50
Modify Date: 2024-01-02 10:23:45
Esfenvalerate is one of the four isomers of the pyrethroid insecticide fenvalerate[1].

Name	Esfenvalerate
Synonyms	Sumi-α (S-(R,R))-Cyano(3-phenoxyphenyl)methyl 4-chloro-2-(1-methylethyl)benzeneacetate (S)-α-Cyano-3-phenoxybenzyl (S)-2-(4-chlorophenyl)-3-methylbutyrate (S)-Cyano(3-phenoxyphenyl)methyl (2S)-2-(4-chlorophenyl)-3-methylbutanoate Asana Asana XL Halmark S,S-fenvalerate Esfenvalerate (S)-a-Cyano-3-phenoxybenzyl (S)-2-(4-chlorophenyl)-3-methylbutyrate (αS)-α-cyano-3-phenoxybenzyl (2S)-2-(4-chlorophenyl)-3-methylbutyrate MFCD00203302 Benzeneacetic acid, 4-chloro-α-(1-methylethyl)-, (S)-cyano(3-phenoxyphenyl)methyl ester, (αS)- (S)-cyano(3-phenoxyphenyl)methyl (αS)-4-chloro-α-(1-methylethyl)benzeneacetate Fenvalerate (S,S)-isomer

Description	Esfenvalerate is one of the four isomers of the pyrethroid insecticide fenvalerate[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vivo	Esfenvalerate (0.1, 1, 7.5 or 15 mg/kg/day; gavage; from gestation day (GD) 13 to 19) shows clinical signs of neurotoxicity with 15 mg/kg/day[1].
References	[1]. Anne-Marie Saillenfait, et al. The Pyrethroid Insecticides Permethrin and Esfenvalerate Do Not Disrupt Testicular Steroidogenesis in the Rat Fetus. Toxicology. 2018 Dec 1;410:116-124.

Density	1.2±0.1 g/cm3
Boiling Point	538.9±50.0 °C at 760 mmHg
Melting Point	59°C
Molecular Formula	C₂₅H₂₂ClNO₃
Molecular Weight	419.900
Flash Point	279.7±30.1 °C
Exact Mass	419.128815
PSA	59.32000
LogP	6.68
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.586

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CY1576367

CHEMICAL NAME :: Benzeneacetic acid, 4-chloro-alpha-(1-methylethyl)-, cyano (3-phenoxyphenyl)methyl ester, (S-(R*,R*))-

CAS REGISTRY NUMBER :: 66230-04-4

LAST UPDATED :: 199710

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C25-H22-Cl-N-O3

MOLECULAR WEIGHT :: 419.93

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 325 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C287,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C287,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C27,1991 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 53,309,1991 IARC Cancer Review:Human No Available Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 53,309,1991 IARC Cancer Review:Group 3 IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 53,309,1991

Symbol	GHS06, GHS09
Signal Word	Danger
Hazard Statements	H301 + H331-H317-H410
Precautionary Statements	P261-P273-P280-P301 + P310 + P330-P304 + P340 + P312-P403 + P233
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T:Toxic;N:Dangerousfortheenvironment;
Risk Phrases	R23/25;R43;R50/53
Safety Phrases	S24-S36/37/39-S45-S60-S61
RIDADR	UN 2811
RTECS	CY1576367
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2926909090

956498-38-7

~23%

67614-32-8

66230-04-4

Literature: COUNCIL OF SCIENTIFIC and INDUSTRIAL RESEARCH Patent: US2006/128982 A1, 2006 ; Location in patent: Page/Page column 16; 17; 19-21; 24; 25 ;

143-33-9

66230-05-5

39515-51-0

~35%

66230-04-4

Literature: Reddy, Ch. Venkateshwar; Mahesh; Raju; Reddy, V.V. Narayana Synthetic Communications, 2002 , vol. 32, # 18 p. 2797 - 2802

51631-50-6

39515-47-4

67614-32-8

66230-04-4

Literature: Tetrahedron Asymmetry, , vol. 12, # 12 p. 1695 - 1699

39515-51-0

66230-04-4

Literature: Journal of Agricultural and Food Chemistry, , vol. 47, # 5 p. 2145 - 2155

Precursor 7
143-33-9 66230-05-5 39515-51-0 51631-50-6
39515-47-4 2012-74-0 55332-38-2
DownStream 0

HS Code	2926909090
Summary	HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%