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56512-49-3

56512-49-3 structure
56512-49-3 structure
  • Name: Dabsyl chloride
  • Chemical Name: dabsyl chloride
  • CAS Number: 56512-49-3
  • Molecular Formula: C14H14ClN3O2S
  • Molecular Weight: 323.79800
  • Catalog: Chemical reagent Organic reagent Acid halide
  • Create Date: 2018-02-24 08:00:00
  • Modify Date: 2024-01-10 18:22:46
  • Dabsyl chloride is an amine derivatizing agent, able to give rise to stable products that can be easily monitored spectrophotometrically at 460 nm; Dabsyl chloride also used for labeling amino acids.

Name dabsyl chloride
Synonyms EINECS 260-235-1
4-[[4-(dimethylamino)phenyl]diazenyl]benzenesulfonyl chloride
MFCD00007444
Description Dabsyl chloride is an amine derivatizing agent, able to give rise to stable products that can be easily monitored spectrophotometrically at 460 nm; Dabsyl chloride also used for labeling amino acids.
Related Catalog
In Vitro Dabsyl chloride can give rise to mono-Dabsyl and bis-Dabsyl derivatives in the presence of multiple amino groups. Furthermore with respect to OPA derivatization, Dabsyl chloride can react with primary and also with secondary amines[1].
Cell Assay Selected mouse brain samples from either cortical or striatal regions (100 mg wet weight) and neuroblastoma cells (SH-SY5Y) pellet derived from 25 cm2 flask are treated with 500 μL of 0.1 M HCl containing 0.2% TDGA, sonicated for 10 min (only for brain tissue), and then centrifuged at 14000 g for 30 min. The supernatant is freeze-dried. 50 μL of reaction buffer and 100 μL of 15 mM Dabsyl chloride are added to the tube and derivatized.
References

[1]. Francioso A, et al. HPLC Determination of Bioactive Sulfur Compounds, Amino Acids and Biogenic Amines in Biological Specimens. Adv Exp Med Biol. 2017;975:535-549.

Density 1.29 g/cm3
Boiling Point 483.6ºC at 760 mmHg
Melting Point 185 °C (dec.)(lit.)
Molecular Formula C14H14ClN3O2S
Molecular Weight 323.79800
Flash Point 246.3ºC
Exact Mass 323.05000
PSA 70.48000
LogP 5.17630
Index of Refraction 1.607
Storage condition −20°C
Water Solubility DMF: soluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DB8927800
CHEMICAL NAME :
Benzenesulfonyl chloride, p-((p-(dimethylamino)phenyl)azo)-
CAS REGISTRY NUMBER :
56512-49-3
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C14-H14-Cl-N3-O2-S
MOLECULAR WEIGHT :
323.82

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Unscheduled DNA synthesis
TEST SYSTEM :
Rodent - hamster Liver
DOSE/DURATION :
10 umol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 5,1,1983
Symbol GHS05
GHS05
Signal Word Danger
Hazard Statements H314
Precautionary Statements P280-P305 + P351 + P338-P310
Personal Protective Equipment Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes C
Risk Phrases R22;R34
Safety Phrases S26-S36/37/39-S45-S27
RIDADR UN 3261 8/PG 2
WGK Germany 3
RTECS DB8927800
Packaging Group II
Hazard Class 8
HS Code 2927000090
HS Code 2927000090
Summary 2927000090 other diazo-, azo- or azoxy-compounds。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%