66852-01-5

66852-01-5 structure
66852-01-5 structure
  • Name: Tyrosylleucine TFA
  • Chemical Name: L-Tyr-L-Leu-OH trifluoroacetate
  • CAS Number: 66852-01-5
  • Molecular Formula: C17H23F3N2O6
  • Molecular Weight: 408.37
  • Catalog: Research Areas Neurological Disease
  • Create Date: 2017-06-29 12:00:20
  • Modify Date: 2024-01-03 13:23:55
  • Tyrosylleucine (Tyr-Leu, YL) TFA, an orally active dipeptide, exhibits a potent antidepressant-like activity[1].

Name L-Tyr-L-Leu-OH trifluoroacetate
Description Tyrosylleucine (Tyr-Leu, YL) TFA, an orally active dipeptide, exhibits a potent antidepressant-like activity[1].
Related Catalog
In Vitro Tyrosylleucine (Tyr-Leu, YL) increases the amount of cells expressing c-Fos, a marker for neuronal activity, in the dentate gyrus of the hippocampus[1].
In Vivo Tyrosylleucine (Tyr-Leu, YL) dose-dependently exhibits potent anxiolytic-like activity (0.1-1 mg/kg, i.p.)[2].
References

[1]. Takafumi Mizushige, et al. Dipeptide tyrosyl-leucine exhibits antidepressant-like activity in mice. Sci Rep. 2020 Feb 10;10(1):2257.

[2]. Norimasa Kanegawa, et al. Dipeptide Tyr-Leu (YL) exhibits anxiolytic-like activity after oral administration via activating serotonin 5-HT1A, dopamine D1 and GABAA receptors in mice. FEBS Lett. 2010 Feb 5;584(3):599-604.

Molecular Formula C17H23F3N2O6
Molecular Weight 408.37
Exact Mass 408.15100
PSA 149.95000
LogP 2.60200
Precursor  0

DownStream  2