Tyrosylleucine TFA

Modify Date: 2025-08-27 22:33:03

Tyrosylleucine TFA structure	Common Name	Tyrosylleucine TFA
	CAS Number	66852-01-5	Molecular Weight	408.37
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₇H₂₃F₃N₂O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Tyrosylleucine TFA

Tyrosylleucine (Tyr-Leu, YL) TFA, an orally active dipeptide, exhibits a potent antidepressant-like activity[1].

Name	L-Tyr-L-Leu-OH trifluoroacetate

Description	Tyrosylleucine (Tyr-Leu, YL) TFA, an orally active dipeptide, exhibits a potent antidepressant-like activity[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	Tyrosylleucine (Tyr-Leu, YL) increases the amount of cells expressing c-Fos, a marker for neuronal activity, in the dentate gyrus of the hippocampus[1].
In Vivo	Tyrosylleucine (Tyr-Leu, YL) dose-dependently exhibits potent anxiolytic-like activity (0.1-1 mg/kg, i.p.)[2].
References	[1]. Takafumi Mizushige, et al. Dipeptide tyrosyl-leucine exhibits antidepressant-like activity in mice. Sci Rep. 2020 Feb 10;10(1):2257. [2]. Norimasa Kanegawa, et al. Dipeptide Tyr-Leu (YL) exhibits anxiolytic-like activity after oral administration via activating serotonin 5-HT1A, dopamine D1 and GABAA receptors in mice. FEBS Lett. 2010 Feb 5;584(3):599-604.

Precursor 0
DownStream 2
CAS#:61-90-5 L-leucine CAS#:60-18-4 L-Tyrosine

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