57719-81-0
57719-81-0 structure
- Name: ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid
- Chemical Name: (4R,4aS,6aR,9S,11S,11aS,11bR)-11-hydroxy-4,11b-dimethyl-8-methylene-7-oxotetradecahydro-6a,9-methanocyclohepta[a]naphthalene-4-carboxylic acid
- CAS Number: 57719-81-0
- Molecular Formula: C20H28O4
- Molecular Weight: 332.43
- Catalog: Natural product Moss
- Create Date: 2016-03-27 22:40:24
- Modify Date: 2025-08-25 17:00:10
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ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid is an anti-melanin synthesis tyrosinase inhibitor, which can be isolated from Pteris fern. ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid regulates the melanogenesis transcription factor microphthalmia-associated transcription factor (MITF). The 11α-OH, 15-oxo and 16-en moieties of ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid are key fragments that inhibit melanin synthesis. The 19-COOH moiety has been implicated in the inhibition of cytotoxicity associated with 11α-OH KA and related compounds[1].
| Name | (4R,4aS,6aR,9S,11S,11aS,11bR)-11-hydroxy-4,11b-dimethyl-8-methylene-7-oxotetradecahydro-6a,9-methanocyclohepta[a]naphthalene-4-carboxylic acid |
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| Synonyms | (5β,8α,9β,10α,11β,13α)-11-Hydroxy-15-oxokaur-16-en-18-oic acid |
| Description | ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid is an anti-melanin synthesis tyrosinase inhibitor, which can be isolated from Pteris fern. ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid regulates the melanogenesis transcription factor microphthalmia-associated transcription factor (MITF). The 11α-OH, 15-oxo and 16-en moieties of ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid are key fragments that inhibit melanin synthesis. The 19-COOH moiety has been implicated in the inhibition of cytotoxicity associated with 11α-OH KA and related compounds[1]. |
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| References |
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 516.6±50.0 °C at 760 mmHg |
| Molecular Formula | C20H28O4 |
| Molecular Weight | 332.43 |
| Flash Point | 280.3±26.6 °C |
| Exact Mass | 332.198761 |
| PSA | 74.60000 |
| LogP | 2.17 |
| Vapour Pressure | 0.0±3.0 mmHg at 25°C |
| Index of Refraction | 1.576 |
| Hazard Codes | Xi |
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