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57149-08-3

57149-08-3 structure
57149-08-3 structure
  • Name: Naftopidil dihydrochloride
  • Chemical Name: 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol,dihydrochloride
  • CAS Number: 57149-08-3
  • Molecular Formula: C24H30Cl2N2O3
  • Molecular Weight: 392.491
  • Catalog: API Circulatory system medication Prevention and treatment of angina pectoris
  • Create Date: 2018-07-31 15:53:06
  • Modify Date: 2025-08-24 10:27:54
  • Naftopidil dihydrochloride (KT-611 dihydrochloride) is a selective alpha1-adrenoceptor antagonist, with antiproliferative effects. Naftopidil dihydrochloride can be used for the research of prostate hyperplasia[1].
Name 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol,dihydrochloride
Synonyms Avishot
Naftopidil DiHCl
KT-611 dihydrochloride
Naftopidildihydrochloride
RS-1-[4-(2-Methoxyphenyl)-1-piperazinyl]-3-(1-naphthoxy)-2-propanol
flivas dihydrochloride
1-(2-Methoxyphenyl)-4-[3-(naphth-1-yloxy)-2-hydroxypropyl]-piperazine
4-(2-Methoxyphenyl)-a-[(1-naphthalenyloxy)methyl]-1-piperazineethanol
S1387_Selleck
Flivas
1-[4-(2-Methoxyphenyl)-1-piperazinyl]-3-(1-naphthyloxy)-2-propanol
1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-(naphthalen-1-yloxy)propan-2-ol
1-Piperazineethanol, 4-(2-methoxyphenyl)-α-[(1-naphthalenyloxy)methyl]-
Naftopidil
1-[4-(2-Methoxyphenyl)piperazin-1-yl]-3-(1-naphthyloxy)propan-2-ol
Description Naftopidil dihydrochloride (KT-611 dihydrochloride) is a selective alpha1-adrenoceptor antagonist, with antiproliferative effects. Naftopidil dihydrochloride can be used for the research of prostate hyperplasia[1].
Related Catalog
Target

α1-adrenoceptor[1]

In Vitro Naftopidil dihydrochloride suppresses human prostate tumor growth by altering interactions between tumor cells and stroma[1]. Naftopidil dihydrochloride (10 μM for PCa cells; 0.1-10 Μm for PrSC) shows growth inhibitory effects on PrSC and PCa cells[1]. Naftopidil dihydrochloride (50 μM for E9 cells, 25 μM for PrSC; 48 hours) increased the level of cell-cycle regulatory protein p27 in E9 cells, but not PrSC[1]. Cell Proliferation Assay[1] Cell Line: PCa cells, PrSC Concentration: 10 μM (PCa cells); 0.1 μM, 1 μM, 10 μM (PrSC) Incubation Time: 3 days Result: Exhibited growth inhibitory effects on PCa cells, PrSC in dose-dependent manners. Western Blot Analysis[1] Cell Line: PCa cells, PrSC Concentration: 50 μM (E9 cells), 25 μM (PrSC) Incubation Time: 48 hours Result: Increased the level of cell-cycle regulatory protein p27 in E9 cells, but not PrSC.
In Vivo Naftopidil dihydrochloride (10 mg/kg; p.o; daily, for 28 days) decreases microvessel density (MVD) in E9 + PrSC tumors mice model[1]. Male athymic mice(7-8 weeks), with E9 + PrSC xenograft [1] Animal Model: Male athymic mice(7-8 weeks), with E9 + PrSC xenograft [1] Dosage: 10 mg/kg Administration: Oral administration, daily, for 28 days Result: Decrease tumor weights.
References

[1]. Yasuhide Hori, et al. Naftopidil, a selective {alpha}1-adrenoceptor antagonist, suppresses human prostate tumor growth by altering interactions between tumor cells and stroma. Cancer Prev Res (Phila). 2011 Jan;4(1):87-96.
Density 1.2±0.1 g/cm3
Boiling Point 602.8±55.0 °C at 760 mmHg
Melting Point 212-213°
Molecular Formula C24H30Cl2N2O3
Molecular Weight 392.491
Flash Point 318.3±31.5 °C
Exact Mass 392.209991
PSA 45.17000
LogP 4.81
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.619
Storage condition -20℃
Water Solubility methanol: >10 mg/mL
WGK Germany 3
RTECS TL9336500
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