1428-95-1

1428-95-1 structure

Name: 5-(N,N-Hexamethylene)-amiloride
Chemical Name: 5-(N,N-hexamethylene)amiloride
CAS Number: 1428-95-1
Molecular Formula: C₁₂H₁₈ClN₇O
Molecular Weight: 311.77100
Catalog: API Urinary system medication Diuretic
Create Date: 2018-03-11 08:00:00
Modify Date: 2025-08-22 15:11:41
5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) derives from an amiloride and is a potent Na+/H+ exchanger inhibitor, which decreases the intracellular pH (pHi) and induces apoptosis in leukemic cells. 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) is also an inhibitor of the HIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC50s of 3.91 μM and 1.34 μM, respectively[1][2].

Name	5-(N,N-hexamethylene)amiloride
Synonyms	HMA 3-amino-5-azepan-1-yl-6-chloro-pyrazine-2-carboxylic acid carbamimidoylamide HMA-5 3-amino-5-(azepan-1-yl)-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide Hexamethyleneamiloride

Description	5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) derives from an amiloride and is a potent Na+/H+ exchanger inhibitor, which decreases the intracellular pH (pHi) and induces apoptosis in leukemic cells. 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) is also an inhibitor of the HIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC50s of 3.91 μM and 1.34 μM, respectively[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Cancer Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection
Target	Na+/H+ exchanger[1] EC50: 3.91 μM (MHV replication), 1.34 μM (HCoV229E replication)[2]
References	[1]. Rich IN, et al. Apoptosis of leukemic cells accompanies reduction in intracellular pH after targeted inhibition of the Na(+)/H(+) exchanger. Blood. 2000 Feb 15;95(4):1427-34. [2]. Wilson L, et al. Hexamethylene amiloride blocks E protein ion channels and inhibits coronavirus replication. Virology. 2006 Sep 30;353(2):294-306. Epub 2006 Jul 3.

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301-H311-H331
Precautionary Statements	P261-P280-P301 + P310-P311
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T
Risk Phrases	23/24/25
Safety Phrases	22-36/37/39-45
RIDADR	UN 2811
WGK Germany	3
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2934999090

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%