280782-97-0
280782-97-0 structure
- Name: Managlinat dialanetil
- Chemical Name: 2-amino-4-{2-[5-(N,N'-bis((R,S)-1-(1-ethoxycoarbonyl)ethyl)phosphonamido)]furanyl}-5-isobutylthiazole
- CAS Number: 280782-97-0
- Molecular Formula: C21H33N4O5PS
- Molecular Weight: 500.549
- Catalog: Signaling Pathways Others Others
- Create Date: 2018-09-18 02:07:46
- Modify Date: 2024-01-09 17:18:40
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Managlinat dialanetil (MB06322) is an orally bioavailable inhibitor of fructose 1,6-bisphosphatase (FBPase) for the treatment of type 2 diabetes[1] [2].
| Name | 2-amino-4-{2-[5-(N,N'-bis((R,S)-1-(1-ethoxycoarbonyl)ethyl)phosphonamido)]furanyl}-5-isobutylthiazole |
|---|---|
| Synonyms |
MANAGLINAT DIALANETIL/CS-917
ethyl (2S,6S)-4-{5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl}-2,6-dimethyl-7-oxo-8-oxa-3,5-diaza-4-phosphadecan-1-oate 4-oxide (non-preferred name) ethyl 4-[5-(2-amino-5-isobutyl-1,3-thiazol-4-yl)-2-furyl]-2,6-dimethyl-7-oxo-8-oxa-3,5-d iaza-4-phosphadecan-1-oate 4-oxide Ethyl (2S,6S)-4-[5-(2-amino-5-isobutyl-1,3-thiazol-4-yl)-2-furyl]-2,6-dimethyl-7-oxo-8-oxa-3,5-diaza-4-phosphadecan-1-oate 4-oxide Managlinat dialanetil managlinat dialantenil |
| Description | Managlinat dialanetil (MB06322) is an orally bioavailable inhibitor of fructose 1,6-bisphosphatase (FBPase) for the treatment of type 2 diabetes[1] [2]. |
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| Related Catalog | |
| Target |
FBPase[1][2] |
| In Vivo | Managlinat dialanetil dose-dependently inhibits GNG as well as lower basal and postprandial blood glucose levels in Zucker diabetic fatty (ZDF) rats after oral administration[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 634.8±65.0 °C at 760 mmHg |
| Molecular Formula | C21H33N4O5PS |
| Molecular Weight | 500.549 |
| Flash Point | 337.7±34.3 °C |
| Exact Mass | 500.185852 |
| PSA | 183.83000 |
| LogP | 2.57 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.552 |
| Hazard Codes | Xn |
|---|