1226781-44-7

1226781-44-7 structure

Name: Omarigliptin
Chemical Name: Omarigliptin
CAS Number: 1226781-44-7
Molecular Formula: C₁₇H₂₀F₂N₄O₃S
Molecular Weight: 398.427
Catalog: Biochemical Inhibitor Proteases DPP-4 inhibitor
Create Date: 2018-04-04 08:00:00
Modify Date: 2024-01-02 15:11:46
Omarigliptin(MK-3102) is a potent, selective and long-acting DPP-4 inhibitor with IC50 of 1.6 nM; highly selective over allproteases tested (IC50 > 67 μM).IC50 value: 1.6 nM [1]Target: DPP-4 inhibitorin vitro: Omarigliptin has weak ion channel activity (IC50 > 30 μM at IKr, Cav1.2, and Nav1.5). An expansive selectivity counterscreen (168 radioligand binding or enzymatic assays) was carried out at MDS Pharma. An IC50 > 10 μM was obtained in all assays. in vivo: When orally administered 1 h prior to dextrose challenge in an oral glucose tolerance test (OGTT), it significantly reduced blood glucose excursion in a dose-dependent manner from 0.01 mg/kg (7% reduction in glucose AUC) to 0.3 mg/kg (51% reduction).

Name	Omarigliptin
Synonyms	UNII-CVP59Q4JE1 (2R,3S,5R)-2-(2,5-difluorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]-tetrahydro-2H-pyran-3-amine MK-3102 Omarigliptin (2R,3S,5R)-2-(2,5-Difluorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-2H-pyran-3-amine 2H-Pyran-3-amine, 2-(2,5-difluorophenyl)-5-[2,6-dihydro-2-(methylsulfonyl)pyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-, (2R,3S,5R)- MK-3102

Description	Omarigliptin(MK-3102) is a potent, selective and long-acting DPP-4 inhibitor with IC50 of 1.6 nM; highly selective over allproteases tested (IC50 > 67 μM).IC50 value: 1.6 nM [1]Target: DPP-4 inhibitorin vitro: Omarigliptin has weak ion channel activity (IC50 > 30 μM at IKr, Cav1.2, and Nav1.5). An expansive selectivity counterscreen (168 radioligand binding or enzymatic assays) was carried out at MDS Pharma. An IC50 > 10 μM was obtained in all assays. in vivo: When orally administered 1 h prior to dextrose challenge in an oral glucose tolerance test (OGTT), it significantly reduced blood glucose excursion in a dose-dependent manner from 0.01 mg/kg (7% reduction in glucose AUC) to 0.3 mg/kg (51% reduction).
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Dipeptidyl Peptidase Research Areas >> Metabolic Disease
References	[1]. Biftu T, et al. Omarigliptin (MK-3102): a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes. J Med Chem. 2014 Apr 24;57(8):3205-12.

Density	1.6±0.1 g/cm3
Boiling Point	529.4±60.0 °C at 760 mmHg
Molecular Formula	C₁₇H₂₀F₂N₄O₃S
Molecular Weight	398.427
Flash Point	274.0±32.9 °C
Exact Mass	398.122406
PSA	98.83000
LogP	0.46
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.689
Storage condition	-20℃

1226781-87-8

~89%

1226781-44-7

Literature: Biftu, Tesfaye; Sinha-Roy, Ranabir; Chen, Ping; Qian, Xiaoxia; Feng, Dennis; Kuethe, Jeffrey T.; Scapin, Giovanna; Gao, Ying Duo; Yan, Youwei; Krueger, Davida; Bak, Annette; Eiermann, George; He, Jiafang; Cox, Jason; Hicks, Jacqueline; Lyons, Kathy; He, Huaibing; Salituro, Gino; Tong, Sharon; Patel, Sangita; Doss, George; Petrov, Aleksandr; Wu, Joseph; Xu, Shiyao Sherrie; Sewall, Charles; Zhang, Xiaoping; Zhang, Bei; Thornberry, Nancy A.; Weber, Ann E. Journal of Medicinal Chemistry, 2014 , vol. 57, # 8 p. 3205 - 3212

1280210-80-1

1226781-44-7

Literature: MERCK SHARP and DOHME CORP.; ARROYO, Itzia; KRUEGER, Davida; CHEN, Ping; MOMENT, Aaron; BIFTU, Tesfaye; SHEEN, Faye; ZHANG, Yanfeng; MERCK SHARPE and DOHME LTD. Patent: WO2013/3249 A1, 2013 ;