115931-65-2

115931-65-2 structure

Name: CL-275838
Chemical Name: 4-[2-(4-benzylpiperazin-1-yl)acetyl]-7-[3-(trifluoromethyl)phenyl]-5H-pyrazolo[1,5-a]pyrimidine-3-carbonitrile
CAS Number: 115931-65-2
Molecular Formula: C₂₇H₂₅F₃N₆O
Molecular Weight: 506.52200
Catalog: Research Areas Neurological Disease
Create Date: 2016-09-25 15:52:49
Modify Date: 2024-04-05 18:37:36
CL-275838 is a memory-enhancing agent, also with potent antidepressant activities.

Name	4-[2-(4-benzylpiperazin-1-yl)acetyl]-7-[3-(trifluoromethyl)phenyl]-5H-pyrazolo[1,5-a]pyrimidine-3-carbonitrile
Synonyms	CL-275838

Description	CL-275838 is a memory-enhancing agent, also with potent antidepressant activities.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vivo	CL 275,838 metabolism has sex-dependent differences in rat. CL 275,838 does not appreciably affect its own oxidation or cause significant hepatic microsomal enzyme induction in the male or female rat, except for slight enhancement of some components of the P450 system at doses (300 mg/kg once daily for 7 days) well above the effective pharmacological range[1].
References	[1]. Ferrarese A, et al. Hepatic microsomal metabolism of the potential memory-enhancing agent, CL 275,838, to its desbenzyl derivative. Xenobiotica. 1993 Sep;23(9):1007-16.