101491-79-6

101491-79-6 structure

Name: mAChR antagonist 1
Chemical Name: (1-methylpiperidin-4-yl) N,N-diphenylcarbamate
CAS Number: 101491-79-6
Molecular Formula: C₁₉H₂₂N₂O₂
Molecular Weight: 310.39000
Catalog: Signaling Pathways GPCR/G Protein mAChR
Create Date: 2017-03-23 12:35:31
Modify Date: 2024-01-11 16:21:27
mAChR antagonist 1 (compound 4a) is a mAChR antagonist with Ki values of 255 nM, 121 nM, 158 nM, and 255 nM for M1, M3, M4, and M5 subtype, respectively[1].

Name	(1-methylpiperidin-4-yl) N,N-diphenylcarbamate
Synonyms	1-Methyl-4-piperidyl diphenylcarbamate 1-methylpiperidin-4-yl diphenylcarbamate CARBAMIC ACID,DIPHENYL-,1-METHYL-4-PIPERIDYL ESTER

Description	mAChR antagonist 1 (compound 4a) is a mAChR antagonist with Ki values of 255 nM, 121 nM, 158 nM, and 255 nM for M1, M3, M4, and M5 subtype, respectively[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Research Areas >> Neurological Disease
Target	mAChR1:255 nM (Ki) mAChR3:121 nM (Ki) mAChR4:158 nM (Ki) mAChR5:255 nM (Ki) mAChR2:>1000 nM (Ki)
References	[1]. Marlon Millard, et al. Design, synthesis and preclinical evaluation of muscarine receptor antagonists via a scaffold-hopping approach. Eur J Med Chem. 2023 Oct 21:262:115891.