Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Diethylaminoethyl
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Purity: 98.0%
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3563-01-7

3563-01-7 structure

3563-01-7 structure

Name: Diethylaminoethyl
Chemical Name: 2-(Diethylamino)ethyl 2,2-diphenylpropanoate
CAS Number: 3563-01-7
Molecular Formula: C₂₁H₂₇NO₂
Molecular Weight: 325.44500
Catalog: Signaling Pathways GPCR/G Protein mAChR
Create Date: 2018-05-08 08:00:00
Modify Date: 2024-01-05 22:04:45
Aprophen (Aprofene) is an antimuscarinic inhibitor. Aprophen can be used for the research of central nervous system[1].

Name	2-(Diethylamino)ethyl 2,2-diphenylpropanoate
Synonyms	Aprofenum [INN-Latin] Aprophenum 2,2-Diphenyl-propionsaeure-(2-diaethylamino-aethylester) Propionic acid,2,2-diphenyl-,2-(diethylamino)ethyl ester Aprofeno [INN-Spanish] Diphenyl-methyl-essigsaeure-(2-aethyl-diaethylamin)-ester 2-Diethylaminoethyl 2,2-diphenylpropionate Aprofene Aprofen 2,2-diphenyl-propionic acid-(2-diethylamino-ethyl ester) Aprophen

Description	Aprophen (Aprofene) is an antimuscarinic inhibitor. Aprophen can be used for the research of central nervous system[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Research Areas >> Neurological Disease
References	[1]. A comparison of the antimuscarinic properties of aprophen with those of some other anticholinergic drugs. Issue: MRL-R-794. Pages: 10 pp. Report 1980.

Density	1.041g/cm3
Boiling Point	434.8ºC at 760mmHg
Molecular Formula	C₂₁H₂₇NO₂
Molecular Weight	325.44500
Flash Point	132.5ºC
Exact Mass	325.20400
PSA	29.54000
LogP	3.87760
Index of Refraction	1.537

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UF2032500

CHEMICAL NAME :: Propionic acid, 2,2-diphenyl-, 2-(diethylamino)ethyl ester

CAS REGISTRY NUMBER :: 3563-01-7

BEILSTEIN REFERENCE NO. :: 2509326

LAST UPDATED :: 199707

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C21-H27-N-O2

MOLECULAR WEIGHT :: 325.49

WISWESSER LINE NOTATION :: 2N2&2OVX1&R&R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 125 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 4,7,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 370 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 31,53,1968

HS Code	2922199090

86-29-3 structure

86-29-3

~%

3563-01-7 structure

3563-01-7

Literature: Lu, Mattias C.; Wung, Walley E.; Shih, Lisa B.; Callejas, Soledad; Gearien, James E.; Thompson, Emmanuel B. Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 273 - 278

22875-82-7 structure

22875-82-7

~%

3563-01-7 structure

3563-01-7

Literature: Lu, Mattias C.; Wung, Walley E.; Shih, Lisa B.; Callejas, Soledad; Gearien, James E.; Thompson, Emmanuel B. Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 273 - 278

5558-67-8 structure

5558-67-8

~%

3563-01-7 structure

3563-01-7

Literature: Lu, Mattias C.; Wung, Walley E.; Shih, Lisa B.; Callejas, Soledad; Gearien, James E.; Thompson, Emmanuel B. Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 273 - 278

5558-66-7 structure

5558-66-7

~%

3563-01-7 structure

3563-01-7

Literature: Lu, Mattias C.; Wung, Walley E.; Shih, Lisa B.; Callejas, Soledad; Gearien, James E.; Thompson, Emmanuel B. Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 273 - 278

40997-78-2 structure

40997-78-2

100-37-8 structure

100-37-8

~%

3563-01-7 structure

3563-01-7

Literature: Lu, Mattias C.; Wung, Walley E.; Shih, Lisa B.; Callejas, Soledad; Gearien, James E.; Thompson, Emmanuel B. Journal of Medicinal Chemistry, 1987 , vol. 30, # 2 p. 273 - 278

5558-66-7 structure

5558-66-7

100-35-6 structure

100-35-6

~%

3563-01-7 structure

3563-01-7

Literature: Zaugg; Horrom Journal of the American Chemical Society, 1950 , vol. 72, p. 3004,3005

Precursor 5
86-29-3 5558-67-8 5558-66-7 100-37-8
100-35-6
DownStream 0

HS Code	2922199090
Summary	2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%