Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Depramine
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303-54-8

303-54-8 structure

303-54-8 structure

Name: Depramine
Chemical Name: 3-benzo[b][1]benzazepin-11-yl-N,N-dimethylpropan-1-amine
CAS Number: 303-54-8
Molecular Formula: C₁₉H₂₂N₂
Molecular Weight: 278.39
Catalog: Signaling Pathways Neuronal Signaling AChE
Create Date: 2018-07-23 17:57:07
Modify Date: 2024-01-12 13:00:28
Depramine (GP 31406) is a tricyclic antidepressant with pharmacologically activity. Depramine inhibits acetylcholinesterase，Mg2+-ATPase，and Na+/K+ ATPase activity[1][2].

Name	3-benzo[b][1]benzazepin-11-yl-N,N-dimethylpropan-1-amine
Synonyms	(3-dibenzo[b,f]azepin-5-yl-propyl)-dimethyl-amine Depramine Depramina [INN-Spanish] 5-(3-(Dimethylamino)propyl)-5H-dibenz(b,f)azepine 10,11-Dehydroimipramine 5H-Dibenz(b,f)azepine,5-(3-(dimethylamino)propyl) Depraminum [INN-Latin] 5-(8-Dimethylaminopropyl)-iminostilben Balipramine 5-(3'-Dimethyl-amino-propyl)-5H-dibenz<b,f>azepin

Description	Depramine (GP 31406) is a tricyclic antidepressant with pharmacologically activity. Depramine inhibits acetylcholinesterase，Mg2+-ATPase，and Na+/K+ ATPase activity[1][2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE
Target	Acetylcholinesterase (AChE), Mg2+-ATPase, Na+/K+ ATPase[1]
References	[1]. Caratsch CG, et al. Tricyclic antidepressants: action on synaptosomal acetylcholinesterase and ATPase in the brain of guinea pigs and subcellular distribution. Neuropharmacology. 1973 Jun;12(6):563-75.

Density	1.06g/cm3
Boiling Point	413.9ºC at 760mmHg
Molecular Formula	C₁₉H₂₂N₂
Molecular Weight	278.39
Flash Point	185.9ºC
Exact Mass	278.17800
PSA	6.48000
LogP	4.32520
Index of Refraction	1.589

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HO1480000

CHEMICAL NAME :: 5H-Dibenz(b,f)azepine, 5-(3-(dimethylamino)propyl)-

CAS REGISTRY NUMBER :: 303-54-8

BEILSTEIN REFERENCE NO. :: 1319717

LAST UPDATED :: 199712

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C19-H22-N2

MOLECULAR WEIGHT :: 278.43

WISWESSER LINE NOTATION :: T C676 BNJ B3N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 23 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 120,450,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 41 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 120,450,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 6 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 120,450,1959

HS Code	2933990090

256-96-2 structure

256-96-2

109-54-6 structure

109-54-6

~%

303-54-8 structure

303-54-8

Literature: Schmolka; Zimmer Synthesis, 1984 , vol. NO. 1, p. 29 - 31

Precursor 2
256-96-2 109-54-6
DownStream 0

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%