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2135-17-3

2135-17-3 structure
2135-17-3 structure
  • Name: Flumethasone
  • Chemical Name: flumethasone
  • CAS Number: 2135-17-3
  • Molecular Formula: C22H28F2O5
  • Molecular Weight: 410.452
  • Catalog: Biochemical Inhibitor Endocrinology & Hormones Glucocorticoid Receptor Agonist
  • Create Date: 2018-06-14 18:00:08
  • Modify Date: 2025-08-20 19:29:19
  • Flumethasone is a corticosteroid for topical use, in combination with Clioquinol for the treatment of otitis externa and otomycosis. Flumethasone shows fully 420 times the potency of cortisone in an animal model for anti-inflammatory activity.
Name flumethasone
Synonyms Pregna-1,4-diene-3,20-dione, 6α,9-difluoro-11β,17,21-trihydroxy-16α-methyl-
6a-Fluorodexamethasone
Pregna-1,4-diene-3,20-dione, 6,9-difluoro-11,17,21-trihydroxy-16-methyl-, (6α,11β,16α)-
(6α,11β,16α)-6,9-Difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
6α-Fluorodexamethasone
6α,9α-Difluoro-16α-methylprednisolone
Aniprime
Flumethasone
(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-Difluor-17-glycoloyl-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-on
Fluvet
EINECS 218-370-9
flumetasone
6α,9α-Difluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione
Flucorticin
Anaprime
(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-Difluoro-17-glycoloyl-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
MFCD00056464
Flumethason
Cortexilar
6a,9a-Difluoro-16a-methylprednisolone
Methagon
(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
Description Flumethasone is a corticosteroid for topical use, in combination with Clioquinol for the treatment of otitis externa and otomycosis. Flumethasone shows fully 420 times the potency of cortisone in an animal model for anti-inflammatory activity.
Related Catalog
Density 1.4±0.1 g/cm3
Boiling Point 569.8±50.0 °C at 760 mmHg
Melting Point 237-240ºC
Molecular Formula C22H28F2O5
Molecular Weight 410.452
Flash Point 298.4±30.1 °C
Exact Mass 410.190491
PSA 94.83000
LogP 1.61
Vapour Pressure 0.0±3.6 mmHg at 25°C
Index of Refraction 1.579
Storage condition 2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TU3832000
CHEMICAL NAME :
Pregna-1,4-diene-3,20-dione, 6-alpha,9-difluoro-11-beta,17,21-trihydroxy-16-alpha- methyl-
CAS REGISTRY NUMBER :
2135-17-3
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C22-H28-F2-O5
MOLECULAR WEIGHT :
410.50
WISWESSER LINE NOTATION :
L E5 B666 OV AHTTT&J A1 BF CQ E1 FV1 FQ G1 LF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
20 ug/kg
SEX/DURATION :
female 38 week(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 28,407,1972
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
30 ug/kg
SEX/DURATION :
female 31 week(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - abortion
REFERENCE :
JAVMA4 Journal of the American Veterinary Medical Association. (American Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.48- 1915- Volume(issue)/page/year: 160,867,1972
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
20 ug/kg
SEX/DURATION :
female 40 week(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition
REFERENCE :
THGNBO Theriogenology. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022) V.1- 1974- Volume(issue)/page/year: 20,267,1983
Symbol GHS08
GHS08
Signal Word Warning
Hazard Statements H351
Precautionary Statements P281
Personal Protective Equipment Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes Xn:Harmful
Risk Phrases R40
Safety Phrases S22-S36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS TU3832000
HS Code 2937229000
23961-95-7 structure

23961-95-7

~%

2135-17-3 structure

2135-17-3

Literature: WO2012/11106 A1, ; Page/Page column 20 ;
2002-29-1 structure

2002-29-1

~%

2135-17-3 structure

2135-17-3

Literature: Farmaco, , vol. 51, # 12 p. 809 - 810
4571-51-1 structure

4571-51-1

~%

2135-17-3 structure

2135-17-3

Literature: WO2012/11106 A1, ;
HS Code 2937229000
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