32728-78-2

32728-78-2 structure

Name: Heliosupine
Chemical Name: heliosupine
CAS Number: 32728-78-2
Molecular Formula: C₂₀H₃₁NO₇
Molecular Weight: 397.46300
Catalog: Signaling Pathways Neuronal Signaling AChE
Create Date: 2016-03-05 16:09:59
Modify Date: 2024-01-09 16:08:01
Heliosupine is a pyrrolizidine alkaloid. Heliosupine is an acetylcholinesterase (AChE) inhibitor, with an IC50 0.57 mM. Heliosupine exhibits deterrent effects against generalist herbivores[1][2].

Name	heliosupine
Synonyms	Cynoglossofine 7-Angelyl-9-echimidinylheliotridine HELIOSUPINE Heliosupin Cynoglossophine [(7S,8R)-7-[(Z)-2-methylbut-2-enoyl]oxy-5,6,7,8-tetrahydro-3H-pyrrolizin-1-yl]methyl (2S)-2,3-dihydroxy-2-[(1S)-1-hydroxyethyl]-3-methylbutanoate Cynoglossofin

Description	Heliosupine is a pyrrolizidine alkaloid. Heliosupine is an acetylcholinesterase (AChE) inhibitor, with an IC50 0.57 mM. Heliosupine exhibits deterrent effects against generalist herbivores[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Neuronal Signaling >> AChE
Target	IC50: 0.57 mM (AChE)[1]
In Vivo	Heliosupine prevents feeding by the polyphagous larvae of Spodoptera exigua[2].
References	[1]. Benamar H, et, al. Pyrrolizidine alkaloids from Solenanthus lanatus DC. with acetylcholinesterase inhibitory activity. Nat Prod Res. 2016 Nov;30(22):2567-2574. [2]. Dam NM, et, al. The "Raison D'être" of pyrrolizidine alkaloids in Cynoglossum officinale: Deterrent effects against generalist herbivores. J Chem Ecol. 1995 May;21(5):507-23.