DC Chemicals Limited
China
Product Name: Dansylcadaverine (Monodansyl cadaverine)
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 5-DIMETHYLAMINONAPHTHALENE-1-(N-(5-AMINOPENTYL))-SULFONAMIDE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

10121-91-2

10121-91-2 structure

10121-91-2 structure

Name: Dansylcadaverine
Chemical Name: monodansylcadaverine
CAS Number: 10121-91-2
Molecular Formula: C₁₇H₂₅N₃O₂S
Molecular Weight: 335.46400
Catalog: Dye Reagents
Create Date: 2018-09-07 09:33:34
Modify Date: 2024-01-02 15:42:54
Dansylcadaverine is a fluorescent probe.

Name	monodansylcadaverine
Synonyms	Dansylcadaverine N-(5-aminopentyl)-5-(dimethylamino)naphthalene-1-sulfonamide

Description	Dansylcadaverine is a fluorescent probe.
Related Catalog	Signaling Pathways >> Others >> Others Dye Reagents Research Areas >> Others
In Vitro	Detection of Dansylcadaverine fluorescence after SDS-PAGE shows that the amount of actin-thymosin β4 crosslink is very low in the presence of Dansylcadaverine and transglutaminase, while there are large amounts of Dansylcadaverine-labeled thymosin β4 and actin. The amount of cross-link further decreases in the presence of Dansylcadaverine competing for Lys residues of either G-actin or thymosin β4 (100 μM). In the absence of thymosin β4, Dansylcadaverine-labeled actin polymerized to F-actin as revealed by fluorescence detection after native PAGE[1].
Kinase Assay	To determine the time course of transglutamination, thymosin β4 (120 μM) is incubated with Dansylcadaverine (5 mM) in 70 μL buffer consisting of 10 mM Tris-HCl, pH 7.4, 15 mM CaCl2, 3 mM DTT. The reaction is started by addition of 0.1 U transglutaminase. Immediately after addition of the enzyme (t=0) and at indicated times,10 μL are taken from the mixture, diluted in 490 μL 0.1% TFA to stop the reaction and analyzed by HPLC[1].
Cell Assay	MCF7 cells (2.4×104) are seeded into 35 mm plates. After 24 h incubation, CuO NPs are added with an increasing concentration in the presence or absence of 3-Methyladenine (3-MA) for different time periods . The cells are then incubated with 50 mM Dansylcadaverine (MDC) at 37°C for 15 min and washed with 1×PBS three times with 5 min interval. Finally, the cells are observed under a fluorescence microscope[2].
References	[1]. Huff T, et al. Thymosin beta(4) serves as a glutaminyl substrate of transglutaminase. Labeling with fluorescentdansylcadaverine does not abolish interaction with G-actin. FEBS Lett. 1999 Dec 24;464(1-2):14-20. [2]. Laha D, et al. Interplay between autophagy and apoptosis mediated by copper oxide nanoparticles in human breast cancer cells MCF7. Biochim Biophys Acta. 2014 Jan;1840(1):1-9.

Density	1.19g/cm3
Boiling Point	505.5ºC at 760mmHg
Melting Point	137-140ºC
Molecular Formula	C₁₇H₂₅N₃O₂S
Molecular Weight	335.46400
Flash Point	259.5ºC
Exact Mass	335.16700
PSA	83.81000
LogP	4.48510
Vapour Pressure	9.54E-11mmHg at 25°C
Index of Refraction	1.594

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	26-36
RIDADR	NONH for all modes of transport
HS Code	2935009090

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%