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5947-49-9

5947-49-9 structure
5947-49-9 structure
  • Name: Podocarpic acid
  • Chemical Name: podocarpic acid
  • CAS Number: 5947-49-9
  • Molecular Formula: C17H22O3
  • Molecular Weight: 274.35500
  • Catalog: Signaling Pathways Membrane Transporter/Ion Channel TRP Channel
  • Create Date: 2018-08-09 18:25:34
  • Modify Date: 2025-08-21 11:44:08
  • Podocarpic acid is a natural product, which has the best all-round positive effect and acts as a novel TRPA1 activator.
Name podocarpic acid
Synonyms 1 4A-DIMETHYL-6-HYDROXY-1 2 3,4A 9 10 10A-OCTAHYDRO-1-PHENANTHRENECARBOXYLIC ACID
MFCD00074825
PODOCARPIC ACID
Einecs 227-706-3
12-HYDROXYPODOCARPA-8,11,13-TRIEN-16-OIC ACID
Description Podocarpic acid is a natural product, which has the best all-round positive effect and acts as a novel TRPA1 activator.
Related Catalog
In Vitro Podocarpic acid anhydride acts as a 1 nM agonist of LXRalpha and beta receptors. It shows over 8-10-fold better activator of LXR receptors compared to one of the natural ligands, 22-(R)-hydroxy cholesterol, in HEK-293 cells[2].
In Vivo Podocarpic acid activates SKN-1 in C. elegans, similar to known Nrf2 activators such as α-lipoic acid (LA). Podocarpic acid- or LA-induced SKN-1 activation also requires TRPodocarpic acid-1: trPodocarpic acid-1 knockdown in glod-4;gst-4p::gfp animals reduces expression of gst-4 to wild-type levels. A and LA supplementation results in a robust Ca2+ flux, which is significantly reduces when the Ca2+-impermeable TRPodocarpic acid-1E1018A channel is present, suggesting that TRPodocarpic acid-1 activation is key for these drugs' function. Finally, Podocarpic acid and LA alleviate the Podocarpic acidthogenic phenotypes of glod-4 animals by reverting the high endogenous MGO and GO to almost wild-type-like levels[1].
References

[1]. Baraka HN. Microbial transformation of podocarpic acid and evaluation of transformation products for antioxidant activity. Planta Med. 2010 May;76(8):815-7.

[2]. Singh S, et al. Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters. Bioorg Med Chem Lett. 2005 Jun 2;15(11):2824-8.
Melting Point 193-196 ℃(lit.)
Molecular Formula C17H22O3
Molecular Weight 274.35500
Exact Mass 274.15700
PSA 57.53000
LogP 3.48710
Storage condition -20°C
HS Code 2916209090
HS Code 2916209090
Summary 2916209090 other cyclanic, cyclenic or cyclotherpenic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%
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