67339-62-2

67339-62-2 structure

Name: ARC-239
Chemical Name: ARC 239 dihydrochloride hydrate
CAS Number: 67339-62-2
Molecular Formula: C₂₄H₂₉N₃O₃
Molecular Weight: 407.51
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2016-02-13 13:19:02
Modify Date: 2024-01-10 17:47:08
ARC 239 is an α2B/C-adrenergic receptor antagonist with pKi of 7.06 and 6.95 for rat kidney α2B and human α2C, respectively. ARC 239 also inhibits 5-HT1A receptor with a Ki of 63.1 nM[1][2].

Name	ARC 239 dihydrochloride hydrate
Synonyms	ARC 239 dihydrochloride,2-[2-(4-(2-Methoxyphenyl)piperazin-1-yl)ethyl]-4,4-dimethyl-1,3-(2H,4H)-isoquinolindionedihydrochloride

Description	ARC 239 is an α2B/C-adrenergic receptor antagonist with pKi of 7.06 and 6.95 for rat kidney α2B and human α2C, respectively. ARC 239 also inhibits 5-HT1A receptor with a Ki of 63.1 nM[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	human α2C-adrenoceptor:6.95 (pKi) Alpha-2C adrenergic receptor:7.06 (pKi) 5-HT1A Receptor:63.1 nM (Ki)
References	[1]. K T Gavin, et al. Alpha 2C-adrenoceptors mediate contractile responses to noradrenaline in the human saphenous vein. Naunyn Schmiedebergs Arch Pharmacol. 1997 Mar;355(3):406-11. [2]. J J Meana, et al. The subtype-selective alpha 2-adrenoceptor antagonists BRL 44408 and ARC 239 also recognize 5-HT1A receptors in the rat brain. Eur J Pharmacol. 1996 Oct 3;312(3):385-8.