147782-19-2
147782-19-2 structure
- Name: DCG IV
- Chemical Name: DCG IV,(2S,2'R,3'R)-2-(2',3'-Dicarboxycyclopropyl)glycine
- CAS Number: 147782-19-2
- Molecular Formula: C7H9NO6
- Molecular Weight: 203.14900
- Catalog: Signaling Pathways GPCR/G Protein mGluR
- Create Date: 2018-12-25 20:23:37
- Modify Date: 2025-08-25 11:48:57
-
DCG-IV is a potent agonist of group II mGluRs with EC50s of 0.35 and 0.09 μM for mGlu2R and mGlu3R, reapectively. DCG-IV is also a competitive antagonist at group I (IC50: mGlu1R/5R=389/630 μM) and III receptors (IC50: mGlu4R/6R/7R/8R= 22.5/39.6/40.1/32 μM). DCG-IV has anticonvulsive and neuroprotective effects[1][2].
| Name | DCG IV,(2S,2'R,3'R)-2-(2',3'-Dicarboxycyclopropyl)glycine |
|---|---|
| Synonyms | dcg iv |
| Description | DCG-IV is a potent agonist of group II mGluRs with EC50s of 0.35 and 0.09 μM for mGlu2R and mGlu3R, reapectively. DCG-IV is also a competitive antagonist at group I (IC50: mGlu1R/5R=389/630 μM) and III receptors (IC50: mGlu4R/6R/7R/8R= 22.5/39.6/40.1/32 μM). DCG-IV has anticonvulsive and neuroprotective effects[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | DCG-IV is also an NMDA receptor agonist in the rat cortical slice[3]. |
| In Vivo | DCG-IV (1-10 mg/kg; i.p.) depresses the phencyclidine (PCP)-induced hyperlocomotion[4]. Animal Model: Male ICR mice weighing about 40 g (PCP-induced locomotor activity)[4] Dosage: 10, 5, or 1 mg/kg Administration: I.p. Result: Reduced spontaneous activities of the animals at 10 or 5 mg/kg. |
| References |
| Density | 1.819 g/cm3 |
|---|---|
| Boiling Point | 503.9ºC at 760 mmHg |
| Molecular Formula | C7H9NO6 |
| Molecular Weight | 203.14900 |
| Flash Point | 258.5ºC |
| Exact Mass | 203.04300 |
| PSA | 137.92000 |
| Vapour Pressure | 1.61E-11mmHg at 25°C |
| Index of Refraction | 1.643 |