126766-32-3

126766-32-3 structure

Name: GR 89696 fumarate
Chemical Name: GR 89696 fumarate,4-[(3,4-Dichlorophenyl)acetyl]-3-(1-pyrrolidinylmethyl)-1-piperazinecarboxylicacidmethylesterfumarate
CAS Number: 126766-32-3
Molecular Formula: C₂₃H₂₉Cl₂N₃O₇
Molecular Weight: 530.39800
Catalog: Signaling Pathways GPCR/G Protein Opioid Receptor
Create Date: 2017-08-26 05:23:23
Modify Date: 2024-01-10 17:47:34
GR 89696 is a highly selective κ2 opioid receptor agonist with potential to prevent pruritus[1].

Name	GR 89696 fumarate,4-[(3,4-Dichlorophenyl)acetyl]-3-(1-pyrrolidinylmethyl)-1-piperazinecarboxylicacidmethylesterfumarate

Description	GR 89696 is a highly selective κ2 opioid receptor agonist with potential to prevent pruritus[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> Neuronal Signaling >> Opioid Receptor
In Vivo	GR 89696 (intramuscular injection, 0.01-0.1 μg/kg) 可以以一种剂量依赖的方式减轻鞘内注射吗啡（0.03mg)诱导的抓挠反应而不影响吗啡镇痛作用[1]。 GR-896960(subcutaneous injection, 1 mg/kg) 在大鼠永久性局灶性缺血模型中，使大脑动脉梗塞体积减少了 38%[2]。
References	[1]. Mei-Chuan Ko, et al. Effects of atypical kappa-opioid receptor agonists on intrathecal morphine-induced itch and analgesia in primates. J Pharmacol Exp Ther. 2009 Jan;328(1):193-200. [2]. A Barber, et al. Effects of GR-89696 and the novel peripherally selective OP2 agonists, EMD-61569 and EMD-61747, against focal cerebral ischemia in the rat. Methods Find Exp Clin Pharmacol. 1999 Mar;21(2):105-13

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RIDADR	NONH for all modes of transport