Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine hydrochloride (ZM 306416)
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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Contact: Ms Wang
Email: enquiry@dycnchem.com

690206-97-4

690206-97-4 structure

Name: ZM 306416
Chemical Name: N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine
CAS Number: 690206-97-4
Molecular Formula: C₁₆H₁₃ClFN₃O₂
Molecular Weight: 333.745
Catalog: Biochemical Inhibitor Protein tyrosine kinase
Create Date: 2016-10-10 19:47:45
Modify Date: 2025-08-21 18:00:55
ZM-306416 (CB 676475) is a potent inhibitor of VEGFR with IC50s of 0.1 and 2 μM for KDR and Flt, respectively. ZM-306416 is also a EGFR inhibitor with an IC50 of <10 nM.

Name	N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine
Synonyms	4-Quinazolinamine, N-(4-chloro-2-fluorophenyl)-6,7-dimethoxy- N-(4-Chloro-2-fluorophenyl)-6,7-dimethoxy-4-quinazolinamine N-(4-chloro-2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine Anilinoquinazoline deriv. 4 ZM-306416 ZM306416 ZM 306416

Description	ZM-306416 (CB 676475) is a potent inhibitor of VEGFR with IC50s of 0.1 and 2 μM for KDR and Flt, respectively. ZM-306416 is also a EGFR inhibitor with an IC50 of <10 nM.
Related Catalog	Research Areas >> Cancer
Target	KDR:100 nM (IC50) Flt-1:2 μM (IC50)
In Vitro	ZM-306416 selective anti-proliferative effect toward the EGFR addicted NSCLC cell lines H3255 and HCC4011 (IC50=0.09±0.007 μM and 0.072±0.001 μM respectively), while sparing the wild type EGFR cell lines A549 and H2030 (IC50>10 μM). ZM-306416 is also found to inhibit the ABL in vitro kinase activity with a less potent IC50 value of 1.3±0.2 μM toward the ABL kinase[2].
References	[1]. Han SY, Park SS, Lee WG, Synthesis of a novel biotin-tagged photoaffinity probe for VEGF receptor tyrosine kinases. Bioorg Med Chem Lett. 2006 Jan 1;16(1):129-33. [2]. Antczak C, Mahida JP, Bhinder B, A high-content biosensor-based screen identifies cell-permeable activators and inhibitors of EGFR function: implications in drug discovery. J Biomol Screen. 2012 Aug;17(7):885-99.