15332-10-2
15332-10-2 structure
- Name: DFB
- Chemical Name: DFB,[(3-Fluorophenyl)methylene]hydrazone-3-fluorobenzaldehyde
- CAS Number: 15332-10-2
- Molecular Formula: C14H10F2N2
- Molecular Weight: 244.23900
- Catalog: Signaling Pathways GPCR/G Protein mGluR
- Create Date: 2017-11-25 15:40:12
- Modify Date: 2024-01-02 17:34:56
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3,3'-Difluorobenzaldazine (DFB) is a selective positive allosteric modulator of mGluR5. 3,3'-Difluorobenzaldazine potentiates 3- to 6-fold action for mGlu5 agonists (Glutamate, Quisqualate, and 3,5-Dihydroxyphenylglycine), with EC50s in the 2 to 5 μM range[1].
| Name | DFB,[(3-Fluorophenyl)methylene]hydrazone-3-fluorobenzaldehyde |
|---|---|
| Synonyms |
m-Fluor-benzaldazin
3,3'-Difluorobenzaldazine 3,3'-DIFLUOROBENZALDAZINE DFB |
| Description | 3,3'-Difluorobenzaldazine (DFB) is a selective positive allosteric modulator of mGluR5. 3,3'-Difluorobenzaldazine potentiates 3- to 6-fold action for mGlu5 agonists (Glutamate, Quisqualate, and 3,5-Dihydroxyphenylglycine), with EC50s in the 2 to 5 μM range[1]. |
|---|---|
| Related Catalog | |
| In Vitro | 3,3'-Difluorobenzaldazine (DFB) causes a concentration-dependent potentiation of the response of human mGluR5 CHO cells to 300 nM glutamate in this assay. The maximal potentiation at this concentration of glutamate is approximately 3.1-fold, with an EC50 for potentiation of 2.6 μM. 3,3'-Difluorobenzaldazine causes similar potentiation of the responses of both human mGluR5 and rat mGluR5 CHO cells to glutamate, quisqualate, and DHPG with comparable potencies[1]. |
| In Vivo | 3,3'-Difluorobenzaldazine (40-100 nmol; icv) attenuates the locomotor hyperactivity, motor incoordination, and cognitive impairment induced by Ketamine[2]. Animal Model: Male NMRI and ICR mice (8-9 weeks, 33-40 g)[2] Dosage: 40-100 nmol (~9.7-24.4 μg) Administration: ICV Result: Attenuated the locomotor hyperactivity, motor incoordination, and cognitive impairment induced by Ketamine. |
| References |
| Density | 1.12g/cm3 |
|---|---|
| Boiling Point | 326.6ºC at 760mmHg |
| Molecular Formula | C14H10F2N2 |
| Molecular Weight | 244.23900 |
| Flash Point | 151.3ºC |
| Exact Mass | 244.08100 |
| PSA | 24.72000 |
| LogP | 3.41780 |
| Vapour Pressure | 0.000406mmHg at 25°C |
| Index of Refraction | 1.539 |
| Symbol |
GHS07, GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H400 |
| Precautionary Statements | P273 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn: Harmful;N: Dangerous for the environment; |
| Risk Phrases | R22 |
| Safety Phrases | S60 |
| RIDADR | UN 3077 9/PG 3 |
| HS Code | 2928000090 |
|
~98%
15332-10-2 |
| Literature: Khan, Khalid M.; Jamil, Waqas; Ambreen, Nida; Taha, Muhammad; Perveen, Shahnaz; Morales, Guillermo A. Ultrasonics Sonochemistry, 2014 , vol. 21, # 3 p. 1200 - 1205 |
| Precursor 1 | |
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| DownStream 0 | |
| HS Code | 2928000090 |
|---|---|
| Summary | 2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0% |