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630-02-4

630-02-4 structure
630-02-4 structure
  • Name: n-Octacosane
  • Chemical Name: octacosane
  • CAS Number: 630-02-4
  • Molecular Formula: C28H58
  • Molecular Weight: 394.76000
  • Catalog: Organic raw materials Hydrocarbon compounds and their derivatives Acyclic hydrocarbon
  • Create Date: 2018-03-30 08:00:00
  • Modify Date: 2025-08-25 10:09:01
  • Octacosane is an endogenous metabolite with antibacterial activity. Octacosane shows high cytotoxicity against murine melanoma B16F10-Nex2 cells besides inducing protection against a grafted subcutaneous melanoma. Octacosane has the larvicidal activity against mosquito Culex quinquefasciatus with the LC50 concentration of 7.2 mg/l[1][2][3].
Name octacosane
Synonyms N-o-Carbomethoxyphenyl-N'-phenylthiourea
Benzoic acid,2-[[(phenylamino)thioxomethyl]amino]-,methyl ester
EINECS 211-125-7
MFCD00009355
n-Octakosan
n-Octacosane
Description Octacosane is an endogenous metabolite with antibacterial activity. Octacosane shows high cytotoxicity against murine melanoma B16F10-Nex2 cells besides inducing protection against a grafted subcutaneous melanoma. Octacosane has the larvicidal activity against mosquito Culex quinquefasciatus with the LC50 concentration of 7.2 mg/l[1][2][3].
Related Catalog
Target

Human Endogenous Metabolite

In Vitro 二十八烷 (12.5-100 μg/ml; 18 小时) 对 B16F10-Nex2 细胞具有很强的细胞毒活性，IC50 值为 41.08 μg/ml[1]。 Cell Cytotoxicity Assay[1] Cell Line: B16F10-Nex2 cells Concentration: 12.5, 25, 50, 100 μg/ml Incubation Time: 18 h Result: Displayed strong cytotoxic activity on B16F10-Nex2 cells, with an IC50 value of 41.08 μg/ml
In Vivo 二十八烷 (500 μg; 在与原始细胞移植相关的外周部位注射; 每天; 35 天) 可显着延缓肿瘤进展，并具有显着的抗肿瘤作用[1]。 Animal Model: C57Bl/6 mice with B16F10-Nex2 Cellsl[1] Dosage: 500 μg Administration: Injected at peripheral sites in relation to the original cell grafting; daily; 35 days Result: Resulted in a significant delay of tumor progression with a significant antitumor effect. The survival rate of treated groups was significantly increased.
References

[1]. Carlos R Figueiredo, et al. Pyrostegia venusta heptane extract containing saturated aliphatic hydrocarbons induces apoptosis on B16F10-Nex2 melanoma cells and displays antitumor activity in vivo. Pharmacogn Mag. 2014 Apr;10(Suppl 2):S363-76.  

[2]. S Rajkumar, et al. Mosquitocidal activities of octacosane from Moschosma polystachyum Linn (lamiaceae). J Ethnopharmacol. 2004 Jan;90(1):87-9.  

[3]. Sameh S M Soliman, et al. Effective targeting of breast cancer cells (MCF7) via novel biogenic synthesis of gold nanoparticles using cancer-derived metabolites. PLoS One. 2020 Oct 6;15(10):e0240156.  

Boiling Point 278 °C15 mm Hg(lit.)
Melting Point 57-62 °C(lit.)
Molecular Formula C28H58
Molecular Weight 394.76000
Flash Point 227 °C
Exact Mass 394.45400
LogP 11.16880
Vapour density 13.6 (vs air)
Vapour Pressure <1 mm Hg ( 20 °C)
Index of Refraction 1.4330 (70ºC)
Stability Stable. Combustible. Incompatible with strong oxidizing agents.
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
Packaging Group II; III
Hazard Class 4.1
HS Code 29011090
HS Code 29011090
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