1135-66-6

1135-66-6 structure

Name: Isolongifolene
Chemical Name: Isolongifolene
CAS Number: 1135-66-6
Molecular Formula: C₁₅H₂₄
Molecular Weight: 204.351
Catalog: Flavors and spices Synthetic spice Hydrocarbon spice Olefin
Create Date: 2018-03-22 08:00:00
Modify Date: 2024-01-02 11:07:13
Isolongifolene ((-)-Isolongifolene) is a tricyclic sesquiterpene isolated from Murraya koenigii. Isolongifolene attenuates Rotenone-induced oxidative stress, mitochondrial dysfunction and apoptosis through the regulation of P13K/AKT/GSK-3β signaling pathways. Isolongifolene has antioxidant, anti-inflammatory, anticancer and neuroprotective properties[1].

Name	Isolongifolene
Synonyms	2H-2,4a-Methanonaphthalene, 1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl- 2H-2,4a-Methanonaphthalene, 1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-, (2S,4aR)- (1R)-2,2,7,7-Tetramethyltricyclo[6.2.1.01.6]undec-5-ene EINECS 214-494-2 (1R,8S)-2,2,7,7-Tetramethyltricyclo[6.2.1.0]undec-5-ene 2H-2,4a-Methanonaphthalene, 1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-, (2S,4aR)-(-)- 2,2,7,7-Tetramethyltricyclo[6.2.1.0]undec-5-ene trans-Isolongifolene 1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyI-2H-2,4a-methanonaphthalene MFCD00042616 UNII:PX6N25M90H iso-Longifolene

Description	Isolongifolene ((-)-Isolongifolene) is a tricyclic sesquiterpene isolated from Murraya koenigii. Isolongifolene attenuates Rotenone-induced oxidative stress, mitochondrial dysfunction and apoptosis through the regulation of P13K/AKT/GSK-3β signaling pathways. Isolongifolene has antioxidant, anti-inflammatory, anticancer and neuroprotective properties[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
In Vitro	Isolongifolene (0-50 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment significantly alleviates Rotenone-induced cytotoxicity in SH-SY5Y cells in a dose-dependent manner[1]. Isolongifolene (10 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment attenuates Rotenone-induced apoptosis in SH-SY5Y cells[1]. Isolongifolene (10 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment attenuates Rotenone induced toxicity by down-regulating Bax, caspases-3, 6, 8 and 9 expression and up-regulating of Bcl-2 expression. Furthermore regulation of p-P13K, p-AKT and p-GSK-3β expression by Isolongifolene[1]. Cell Viability Assay[1] Cell Line: SH-SY5Y neuroblastoma cells Concentration: 0 μM, 1 μM, 2.5 μM, 5 μM, 10 μM, 20 μM and 50 µM Incubation Time: 26 hours Result: Significantly alleviated Rotenone-induced cytotoxicity in SH-SY5Y cells. Apoptosis Analysis[1] Cell Line: SH-SY5Y neuroblastoma cells Concentration: 10 µM Incubation Time: 26 hours Result: Attenuated Rotenone-induced apoptosis in SH-SY5Y cells. Western Blot Analysis[1] Cell Line: SH-SY5Y neuroblastoma cells Concentration: 10 µM Incubation Time: 26 hours Result: Attenuated rotenone induced toxicity by down-regulating Bax, caspases-3, 6, 8 and 9 expression and up-regulating of Bcl-2 expression. Prevented the rotenone-induced decreased phosphorylation of GSK-3β.
References	[1]. Balakrishnan R, et al. Isolongifolene attenuates rotenone-induced mitochondrial dysfunction, oxidative stress and apoptosis. Front Biosci (Schol Ed). 2018 Jan 1;10:248-261.

Density	1.0±0.1 g/cm3
Boiling Point	266.5±7.0 °C at 760 mmHg
Molecular Formula	C₁₅H₂₄
Molecular Weight	204.351
Flash Point	102.6±13.0 °C
Exact Mass	204.187805
LogP	6.36
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.518

Hazard Codes	F+
Risk Phrases	R10
RIDADR	UN 2319 3/PG 3
WGK Germany	3
Packaging Group	III
Hazard Class	3.2
HS Code	2902199090

Precursor 8
475-20-7 16846-09-6 70913-79-0 5989-08-2
1139-17-9 108643-05-6 108643-01-2 108643-04-5
DownStream 1
59056-72-3

HS Code	2902199090
Summary	2902199090 other cyclanes, cyclenes and cyclotherpenes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:2.0%。General tariff:30.0%

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