735-46-6

735-46-6 structure

Name: Hamaudol
Chemical Name: (3S)-3,5-dihydroxy-2,2,8-trimethyl-3,4-dihydropyrano[3,2-g]chromen-6-one
CAS Number: 735-46-6
Molecular Formula: C₁₅H₁₆O₅
Molecular Weight: 276.28500
Catalog: Biochemical Amino acids and their derivatives Tyrosine derivatives
Create Date: 2017-11-13 06:56:57
Modify Date: 2024-01-09 12:42:27
Hamaudol is a chromone isolated from Saposhnikovia divaricata. Hamaudol shows significant inhibitory activity on cyclooxygenase (COX)-1 and COX-2 activities with IC50 values of 0.30, 0.57 mM, respectively, and has potent analgesia and anti-inflammary effects[1][2].

Name	(3S)-3,5-dihydroxy-2,2,8-trimethyl-3,4-dihydropyrano[3,2-g]chromen-6-one
Synonyms	Hamaudol

Description	Hamaudol is a chromone isolated from Saposhnikovia divaricata. Hamaudol shows significant inhibitory activity on cyclooxygenase (COX)-1 and COX-2 activities with IC50 values of 0.30, 0.57 mM, respectively, and has potent analgesia and anti-inflammary effects[1][2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> COX
Target	COX-1:0.3 mM (IC50) COX-2:0.57 mM (IC50)
In Vivo	Hamaudol (Compound 7) increases the potency to exhibit a potent analgesia at doses of 1, 5 and 10 mg/kg in mice, although it do not show clear dose dependency[1].
References	[1]. Okuyama E, et al. Analgesic components of saposhnikovia root (Saposhnikovia divaricata). Chem Pharm Bull (Tokyo). 2001 Feb;49(2):154-60. [2]. Mingshan Zheng, et al. The Constituents Isolated from Peucedanum japonicum Thunb. and their Cyclooxygenase (COX) Inhibitory Activity. Korean Journal of Medicinal Crop Science, 2005, 13(2).