Hamaudol
Modify Date: 2025-08-25 12:00:01
Hamaudol structure
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Common Name | Hamaudol | ||
|---|---|---|---|---|
| CAS Number | 735-46-6 | Molecular Weight | 276.28500 | |
| Density | N/A | Boiling Point | 464.7±45.0 °C at 760 mmHg | |
| Molecular Formula | C15H16O5 | Melting Point | 197.0-197.5 °C | |
| MSDS | N/A | Flash Point | N/A | |
Use of HamaudolHamaudol is a chromone isolated from Saposhnikovia divaricata. Hamaudol shows significant inhibitory activity on cyclooxygenase (COX)-1 and COX-2 activities with IC50 values of 0.30, 0.57 mM, respectively, and has potent analgesia and anti-inflammary effects[1][2]. |
| Name | (3S)-3,5-dihydroxy-2,2,8-trimethyl-3,4-dihydropyrano[3,2-g]chromen-6-one |
|---|---|
| Synonym | More Synonyms |
| Description | Hamaudol is a chromone isolated from Saposhnikovia divaricata. Hamaudol shows significant inhibitory activity on cyclooxygenase (COX)-1 and COX-2 activities with IC50 values of 0.30, 0.57 mM, respectively, and has potent analgesia and anti-inflammary effects[1][2]. |
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| Related Catalog | |
| Target |
COX-1:0.3 mM (IC50) COX-2:0.57 mM (IC50) |
| In Vivo | Hamaudol (Compound 7) increases the potency to exhibit a potent analgesia at doses of 1, 5 and 10 mg/kg in mice, although it do not show clear dose dependency[1]. |
| References |
| Boiling Point | 464.7±45.0 °C at 760 mmHg |
|---|---|
| Melting Point | 197.0-197.5 °C |
| Molecular Formula | C15H16O5 |
| Molecular Weight | 276.28500 |
| Exact Mass | 276.10000 |
| PSA | 79.90000 |
| LogP | 1.88140 |
| InChIKey | VOTLUFSYIRHICX-LBPRGKRZSA-N |
| SMILES | Cc1cc(=O)c2c(O)c3c(cc2o1)OC(C)(C)C(O)C3 |
| Storage condition | 2-8°C |
| Hamaudol |