565-73-1

565-73-1 structure

Name: Sodium oxamate
Chemical Name: oxamic acid sodium salt
CAS Number: 565-73-1
Molecular Formula: C₂H₂NNaO₃
Molecular Weight: 111.032
Catalog: Biochemical Common amino acids and protein drugs
Create Date: 2018-05-17 08:00:00
Modify Date: 2024-01-02 10:31:30
Oxamic acid (oxamate) sodium salt is a lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid sodium salt shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce apoptosis[1][2][3].

Name	oxamic acid sodium salt
Synonyms	Sodium oxamate MFCD00044553 sodium,oxamate Acetic acid, 2-amino-2-oxo-, sodium salt (1:1) Sodium amino(oxo)acetate Oxalic acid monoamide sodium salt Acetic acid, aminooxo-, monosodium salt EINECS 209-290-5 OXAMIC ACID SODIUM SALT

Description	Oxamic acid (oxamate) sodium salt is a lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid sodium salt shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce apoptosis[1][2][3].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Lactate Dehydrogenase
In Vitro	Oxamic acid suppresses the proliferation, migration and invasion of both A2780 and SKOV3 cells[1]. Oxamic acid (10 μM; 24-72 h) inhibits cell proliferation in a dose- and time-dependent manner in both NPC cancer cells[2]. Oxamic acid (0-100 mM; 24 h) induces cell cycle arrest in the G2/M phase in CNE-1 and CNE-2 cells[2]. Oxamic acid (0-100 mM; 48 h) induces apoptosis via caspase-3 activation and the mitochondrial pathway in NPC cells[2]. Oxamic acid (0-100 mM; 24 h) increases ROS levels in NPC cells[2]. Cell Proliferation Assay[2] Cell Line: CNE-1 and CNE-2 cells Concentration: 10 μM Incubation Time: 24-72 hours Result: Showed IC50s of 74.6, 32.4 and 17.8 mM and 62.3, 44.5, 31.6 mM at 24, 48 and 72 h in the CNE-1 and CNE-2 cancer cells, respectively. Apoptosis Analysis[2] Cell Line: 0, 20, 50 and 100 mM Concentration: 10 μM Incubation Time: 48 hours Result: Showed the increasement of early and late apoptotic cells in a dose-dependent manner. Increased the expression of pro-apoptotic Bax and cleaved-caspase-3, while reduced the anti-apoptotic signals of Bcl-2 and pro-caspase-3. Cell Cycle Analysis[2] Cell Line: 0, 20, 50 and 100 mM Concentration: 10 μM Incubation Time: 24 hours Result: Showed a dose-dependent increase in the numbers of CNE-1 and CNE-2 cells in the G2/M phase.
In Vivo	Oxamic acid (intraperitoneal injection; 750 mg/kg; once daily; 3 w) treatment improves the efficacy of tumor inhibition in vivo when combined with irradiation treatment[2]. Animal Model: Female Balb/c nude mice injected with CNE-1 cells[2] Dosage: 750 mg/kg Administration: Intraperitoneal injection; 750 mg/kg; once daily; 3 weeks Result: Inhibited the tumor growth when compared to either oxamate alone or irradiation alone.

Boiling Point	306.3ºC at 760 mmHg
Melting Point	300 °C
Molecular Formula	C₂H₂NNaO₃
Molecular Weight	111.032
Flash Point	139ºC
Exact Mass	110.993240
PSA	83.22000
Storage condition	Store at RT.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	F: Flammable;
Risk Phrases	R22;R24/25
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2924199090

HS Code	2924199090
Summary	2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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