162100-15-4

162100-15-4 structure

Name: SB-215505
Chemical Name: 6-chloro-5-methyl-N-quinolin-4-yl-2,3-dihydroindole-1-carboxamide
CAS Number: 162100-15-4
Molecular Formula: C₁₉H₁₆ClN₃O
Molecular Weight: 337.80300
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2016-11-20 06:50:26
Modify Date: 2025-08-26 13:07:08
SB-215505 is a potent and subtype-selective 5-HT2B receptor antagonist with pKi values of 8.3, 6.77, 7.66 for 5-HT2B, 5-HT2A, 5-HT2C, respectively[1]. SB-215505 increases wakefulness and motor activity in rats[2].

Name	6-chloro-5-methyl-N-quinolin-4-yl-2,3-dihydroindole-1-carboxamide
Synonyms	HMS3262F03 Lopac-S-1068 6-Chloro-5-methyl-1-5-quinolycarbamoyl-indoline

Description	SB-215505 is a potent and subtype-selective 5-HT2B receptor antagonist with pKi values of 8.3, 6.77, 7.66 for 5-HT2B, 5-HT2A, 5-HT2C, respectively[1]. SB-215505 increases wakefulness and motor activity in rats[2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	5-HT2B Receptor:8.3 (pKi) 5-HT2A Receptor:6.77 (pKi) 5-HT2C Receptor:7.66 (pKi)
In Vitro	SB-215505 is 30 fold selective for the 5-HT2B over the 5-HT2A receptor, and only marginally selective over the 5-HT2C receptor[1].
In Vivo	SB-215505 (0.1-1.0 mg/kg; i.p.; two doses) dose-dependently increases wakefulness (W) and decreases IS, PS, SWS-2[2]. Animal Model: Male Sprague-Dawley rats weighing 230-260 g[2] Dosage: 0.1, 0.3 and 1.0 mg/kg Administration: IP; two doses (4 days between two doses) Result: Dose-dependently increased wakefulness (W) and decreased intermediate stage of sleep (IS), paradoxical sleep (PS), SWS-2.
References	[1]. C Reavill, et al. Attenuation of haloperidol-induced catalepsy by a 5-HT2C receptor antagonist. Br J Pharmacol. 1999 Feb;126(3):572-4. [2]. Sandor Kantor, et al. Increased wakefulness, motor activity and decreased theta activity after blockade of the 5-HT2B receptor by the subtype-selective antagonist SB-215505. J Pharmacol. 2004 Aug;142(8):1332-42.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport