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Product Name: Glufosinate
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51276-47-2

51276-47-2 structure

51276-47-2 structure

Name: Glufosinate
Chemical Name: phosphinothricin
CAS Number: 51276-47-2
Molecular Formula: C₅H₁₂NO₄P
Molecular Weight: 181.12700
Catalog: Research Areas Neurological Disease
Create Date: 2018-03-17 08:00:00
Modify Date: 2024-01-04 13:09:01
Glufosinate, a phosphinic acid analogue of glutamic acid, is a herbicide which is converted by plant cells into PT (L-phosphinothricin). Glufosinate exerts neurotoxic activity[1][2].

Name	phosphinothricin
Synonyms	2-amino-4-(hydroxymethylphosphinyl)butyric acid (2RS)-2-amino-4-[hydroxy(methyl)phosphinoyl]butyric acid 4-[hydroxy(methyl)phosphinoyl]-DL-homoalanine 2-amino-4-(hydroxymethylphosphinyl)butanoic acid glufosinate

Description	Glufosinate, a phosphinic acid analogue of glutamic acid, is a herbicide which is converted by plant cells into PT (L-phosphinothricin). Glufosinate exerts neurotoxic activity[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	Glufosinate (1-100 μM; 12DIV) disrupts cell-cell adhesion in differentiated V-SVZ neural stem cells (NSCs)[2]. Glufosinate (1-100 μM; 12DIV) significantly decreases Celsr2 gene expression at 100 μM[2]. Glufosinate impairs ependymal cell capability to synthetize cilia[2].
In Vivo	Glufosinate (10-250 mg/kg; gavage; Daily; on days 6-15 of gestation) indicates maternal toxicity in the groups given 50 or 250 mg/kg in Wistar rats[3]. The Elimination of Glufosinate (oral intubation) in the blood takes place with a half-life of less than 4 hours in male and female rats[3].
References	[1]. Áy Z, et al. The effect of high concentrations of glufosinate ammonium on the yield components of transgenic spring wheat (Triticum aestivum L.) constitutively expressing the bar gene. ScientificWorldJournal. 2012;2012:657945. [2]. Feat-Vetel J, et al. Multiple effects of the herbicide glufosinate-ammonium and its main metabolite on neural stem cells from the subventricular zone of newborn mice. Neurotoxicology. 2018 Dec;69:152-163. [3]. Ebert E, et al. Summary of safety evaluation toxicity studies of glufosinate ammonium. Food Chem Toxicol. 1990 May;28(5):339-49.

Density	1.378 g/cm3
Boiling Point	519.1ºC at 760 mmHg
Melting Point	230ºC
Molecular Formula	C₅H₁₂NO₄P
Molecular Weight	181.12700
Flash Point	267.7ºC
Exact Mass	181.05000
PSA	110.43000
LogP	0.38890
Index of Refraction	1.5

Hazard Codes	Xn
HS Code	2931900090

Precursor 0
DownStream 1
77182-82-2

HS Code	2931900090
Summary	2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%